Effects of Repetitive Peripheral Magnetic Stimulation on Upper-Limb Spasticity and Impairment in Patients With Spastic Hemiparesis: A Randomized, Double-Blind, Sham-Controlled Study
Effects of Repetitive Peripheral Magnetic Stimulation on Upper-Limb Spasticity and Impairment in Patients With Spastic Hemiparesis: A Randomized, Double-Blind, Sham-Controlled Study
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DOI：
10.1016/j.apmr.2014.02.003
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发表时间：
2014-06-01
影响因子：
4.3
通讯作者：
Koenig, Eberhard
中科院分区：
文献类型：
--
作者：
Krewer, Carmen;Hartl, Sandra;Koenig, Eberhard
目的：探讨重复外周磁刺激(RPMS)对痉挛状态和运动功能的短期和长期影响。设计：单中心、随机、双盲、假对照试验。地点：神经康复医院。参与者：66例因中风或创伤性脑损伤导致的重度偏瘫和轻中度痉挛患者。干预组自受伤以来的平均+/-SD时间为26+/-71周或37+/-82周。干预：RPM持续20分钟或假刺激加随后的作业治疗20分钟，每天2次，持续2周。主要观察指标：治疗前、治疗2周结束时、研究治疗结束后2周进行改良Tardieu评分和Fugl-Meyer评估(ARM评分)。结果：83%的腕屈肌、62%的肘屈肌、44%的肘伸肌和10%的腕伸肌存在痉挛(Tardieu>；0)。与假刺激组相比，RPMS组对腕屈肌痉挛有短期疗效(P=0.048)，对肘伸肌有长期疗效(P<0.05)。
Objective: To investigate short-term and long-term effects of repetitive peripheral magnetic stimulation (rpMS) on spasticity and motor function.Design: Monocentric, randomized, double-blind, sham-controlled trial.Setting: Neurologic rehabilitation hospital.Participants: Patients (N=66) with severe hemiparesis and mild to moderate spasticity resulting from a stroke or a traumatic brain injury. The average time +/- SD since injury for the intervention groups was 26 +/- 71 weeks or 37 +/- 82 weeks.Interventions: rpMS for 20 minutes or sham stimulation with subsequent occupational therapy for 20 minutes, 2 times a day, over a 2-week period.Main Outcome Measures: Modified Tardieu Scale and Fugl-Meyer Assessment (arm score), assessed before therapy, at the end of the 2-week treatment period, and 2 weeks after study treatment. Additionally, the Tardieu Scale was assessed after the first and before the third therapy session to determine any short-term effects.Results: Spasticity (Tardieu >0) was present in 83% of wrist flexors, 62% of elbow flexors, 44% of elbow extensors, and 10% of wrist extensors. Compared with the sham stimulation group, the rpMS group showed short-term effects on spasticity for wrist flexors (P=.048), and long-term effects for elbow extensors (P