Subsurface cisterns and their relationship to the neuronal plasma membrane.
Subsurface cisterns and their relationship to the neuronal plasma membrane.
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DOI：
10.1083/jcb.13.3.405
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发表时间：
1962-06
期刊：
影响因子：
--
通讯作者：
ROSENBLUTH J
中科院分区：
文献类型：
--
作者：
ROSENBLUTH J
次表面池 (SSC) 是大的、扁平的、膜限制的囊泡，它们与神经细胞体质膜的内部及其突起的近端部分非常接近。它们存在于周围和中枢神经系统的多种脊椎动物和无脊椎动物神经元中，但不存在于周围的支持细胞中。 SSC的结构为片状，其管腔深度可能小于100埃，宽度可能高达几微米。它们与质膜被约 50 至 80 A 的亮区分开，有时包含一条微弱的中间线。类似于 SSC 的扁平无颗粒池，但结构上不同于典型的颗粒内质网 (ER) 和高尔基膜，也出现在神经元细胞质深处。有人认为，紧密贴合的膜可能会相互作用，导致其各自特性的改变。因此，与地下池相关的神经元质膜斑块可能由于这种关联而具有特殊的性质，导致神经元表面不均匀。讨论了 SSC 在神经元电生理学和代谢方面的可能意义。
Subsurface cisterns (SSC's) are large, flattened, membrane-limited vesicles which are very closely apposed to the inner aspect of the plasma membranes of nerve cell bodies and the proximal parts of their processes. They occur in a variety of vertebrate and invertebrate neurons of both the peripheral and central nervous systems, but not in the surrounding supporting cells. SSC's are sheet-like in configuration, having a luminal depth which may be less than 100 A and a breadth which may be as much as several microns. They are separated from the plasmalemma by a light zone of ∼50 to 80 A which sometimes contains a faint intermediate line. Flattened, agranular cisterns resembling SSC's, but structurally distinct from both typical granular endoplasmic reticulum (ER) and from Golgi membranes, also occur deep in the cytoplasm of neurons. It is suggested that membranes which are closely apposed may interact, resulting in alterations in their respective properties. The patches of neuronal plasmalemma associated with subsurface cisterns may, therefore, have special properties because of this association, resulting in a non-uniform neuronal surface. The possible significance of SSC's in relation to neuronal electrophysiology and metabolism is discussed.