The importance of the measurement of circulating markers in patients with neuroendocrine tumours of the pancreas and gut
The importance of the measurement of circulating markers in patients with neuroendocrine tumours of the pancreas and gut
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DOI：
10.1677/erc.0.0100459
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发表时间：
2003-12-01
影响因子：
3.9
通讯作者：
Erikkson, B
中科院分区：
文献类型：
--
作者：
Ardill, JES;Erikkson, B
测量神经内分泌肿瘤患者的一般和特异性生化标志物有助于诊断，并指示治疗的有效性，它们可用作预后指标。嗜铬粒蛋白A是最普遍有用的标志物，这是非常一致的;它被发现在约90%的转移性神经内分泌肿瘤患者的循环中升高，并且有几个很好的市售试剂盒可以提供可靠的估计。特异性标记物也可用于诊断，并且是治疗有效性的有用指标，特别是在肿瘤体积可能没有肿瘤活性变化那么多的情况下。散发性胰腺神经内分泌肿瘤可能分泌一种以上的肽，这表明预后恶化。由于神经内分泌肿瘤进展的广泛变化，预后指标为临床医生提供了显着的优势，以促进在疾病的最佳阶段进行最佳治疗。嗜铬粒蛋白A和神经激肽A都已被用作中肠类癌肿瘤的有力预后指标。
The measurement of general and specific biochemical markers in patients with neuroendocrine tumours assists with diagnosis and gives an indication of the effectiveness of treatment and they may be used as prognostic indicators. There is much agreement that chromogranin A is the most universally helpful marker; it is found to be elevated in the circulation of about 90% of patients with metastatic neuroendocrine tumours and there are several excellent commercially available kits which give reliable estimations. Specific markers are useful for diagnosis also, and are helpful indicators of the effectiveness of treatment, particularly where tumour bulk may not change as much as tumour activity. Sporadic pancreatic neuroendocrine tumours may secrete more than one peptide and this indicates a worsening prognosis. Because of the wide variation in the progression of neuroendocrine tumours, a prognostic indicator gives a significant advantage to the clinician in order to facilitate optimum treatment at the optimum stage of disease. Both chromogranin A and neurokinin A have been used as powerful prognostic indicators for midgut carcinoid tumours.