Citalopram modulation of neuronal responses to aversive face emotions: a functional MRI study
Citalopram modulation of neuronal responses to aversive face emotions: a functional MRI study
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DOI：
10.1097/wnr.0b013e3282742115
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发表时间：
2007-08-27
期刊：
影响因子：
1.7
通讯作者：
Deakin, J. F. William
中科院分区：
文献类型：
--
作者：
Anderson, Ian M.;Del-Ben, Cristina M.;Deakin, J. F. William
本研究利用血氧水平依赖（BOLD）功能MRI研究了血清素对面部情绪加工的调节。在安慰剂控制的平衡顺序设计中，12名男性志愿者在进行隐蔽的面部情绪识别任务前60分钟静脉注射西酞普兰（75毫克）。愤怒、厌恶和恐惧的面孔会产生BOLD信号反应，这与之前的研究结果基本一致。西酞普兰增强了左后脑岛（连同非预先指定的枕核和视觉皮层）的BOLD信号反应，但减弱了左杏仁核对厌恶面孔的激活和右杏仁核对恐惧面孔的激活。没有发现西酞普兰对愤怒面孔的BOLD反应有调节作用。这些结果表明血清素调节低水平的杏仁核对厌恶刺激的激活。
This study investigated the serotonergic modulation of face emotion processing using blood oxygen level-dependent (BOLD) functional MRI. In a placebo-controlled, balanced order design, intravenous citalopram (75 mg) was given to 12 male volunteers 60 min before a covert face emotion recognition task. Angry, disgusted and fearful faces produced BOLD signal responses, which were broadly consistent with previous findings. Citalopram enhanced the BOLD signal response in the left posterior insula (together with nonprespecified pulvinar and visual cortex) but attenuated activation in the left amygdala to disgusted faces and right amygdala activation to fearful faces. No citalopram modulation of BOLD responses to angry faces were found. These results suggest that serotonin modulates low-level amygdala activation to aversive stimuli.