Posttraumatic stress disorder symptoms after bone marrow transplantation for breast cancer
Posttraumatic stress disorder symptoms after bone marrow transplantation for breast cancer
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DOI：
10.1097/00006842-199805000-00026
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发表时间：
1998-05-01
影响因子：
3.3
通讯作者：
Fields, KK
中科院分区：
文献类型：
--
作者：
Jacobsen, PB;Widows, MR;Fields, KK
目的：根据 DSM 标准的修订，人们对被诊断和治疗危及生命的疾病的成年人中创伤后应激障碍（PTSD）症状的发生提出了疑问。本研究调查了因乳腺癌接受自体骨髓移植（ABMT）的女性中 PTSD 症状的患病率和相关性。方法：参与者为 43 名女性，平均在 19 个月前（范围 = 2 至 62 个月）接受过乳腺癌 ABMT，并且在最近一次随访时没有疾病的临床证据。使用标准化自我报告工具评估创伤后应激障碍（PTSD）症状和生活质量。结果：12% 至 19% 的参与者可能符合 DSM-TV 当前 PTSD 诊断的标准。受教育程度较低、移植时病情较严重且移植住院时间较长的女性报告了更多的 PTSD 症状。更严重的 PTSD 症状与较差的身体健康、心理健康和睡眠质量相关。结论：与之前的研究比较表明，与接受强度较低的乳腺癌治疗相比，接受 ABMT 的女性患 PTSD 的几率更高。这些发现与 PTSD 症状的发展与生命威胁程度相关的观点是一致的。研究结果表明，严重的 PTSD 症状与较差的健康相关生活质量相关，这突显了 PTSD 在该患者群体中的临床意义。
Objective: On the basis of revisions of DSM criteria, questions have been raised concerning the occurrence of posttraumatic stress disorder (PTSD) symptoms among adults who have been diagnosed and treated for life-threatening illnesses. The present study examined the prevalence and correlates of PTSD symptoms among women who had undergone autologous bone marrow transplantation (ABMT) for breast cancer. Methods: Participants were 43 women who had undergone ABMT for breast cancer an average of 19 months previously (range = 2 to 62 months) and had no clinical evidence of disease at their most recent follow-up visit. PTSD symptoms and quality of life were assessed using standardized self-report instruments. Results: Between 12% and 19% of participants were Likely to meet DSM-TV criteria for the current diagnosis of PTSD. Women who were less well educated, had more advanced disease at the time of the transplantation and had longer hospital stays for the transplantation reported more symptoms of PTSD. Greater PTSD symptomatology was associated with reports of poorer physical health, mental health, and sleep quality. Conclusion: Comparisons with previous research suggest that rates of PTSD are higher among women who undergo ABMT as opposed to less intensive forms of breast cancer treatment. These findings are consistent with the view that development of PTSD symptoms is associated with the degree of life threat. The clinical significance of PTSD in this patient population is underscored by findings indicating that greater PTSD symptoms are associated with poorer health-related quality of life.