Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization
Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization
复制标题
靶向微管蛋白聚合的吲哚基抗增殖剂
DOI：
10.2174/1568026616666160530154812
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发表时间：
2017
影响因子：
3.4
通讯作者：
Hai-Liang Zhu
中科院分区：
文献类型：
--
作者：
Ya-Li Sang;Wei-Ming Zhang;Peng-Cheng Lv;Hai-Liang Zhu
吲哚是一种潜在的药物设计先导化合物，因其具有抗肿瘤、抗细菌、抗病毒、抗炎等药用特性，在众多药理上具有重要的应用价值。在过去的十年里，干扰微管聚合，导致细胞周期停滞和细胞凋亡已经成为一种很有前途的癌症治疗方法。因此，能够调节微管组装的吲哚类药物引起了科学家们的极大兴趣。本文综述了近十年来以吲哚为基础的微管蛋白聚合剂的合成、生物活性及SARS研究进展。
Indole is a potential lead for drug design which has been found in numerous pharmaceutically.important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus.and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation.to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy..Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest.among scientists. This review describes the synthesis, bioactivities and SARs of indole-based.agents targeting tubulin polymerization during the past decade.