Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population
Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population
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DOI：
10.1007/s10157-013-0833-5
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发表时间：
2014-06-01
影响因子：
2.3
通讯作者：
Tomita, Kimio
中科院分区：
文献类型：
--
作者：
Shiraishi, Naoki;Kitamura, Kenichiro;Tomita, Kimio
肾硬化/缺血性肾病（NS/IN）在日本需要透析的肾脏疾病中排名第三。虽然它是一种重要的肾脏疾病的频率，其患病率，新的发病率和危险因素尚未完全阐明。我们分析了NS/IN的患病率，发病率，并发症和危险因素，通过使用2008年至2010年期间熊本公民的特定健康检查数据。虽然NS/IN的患病率在40多岁的人中为1- 2%，随着年龄的增长，这一比例急剧上升，70-74岁的人达到17.6%。新发NS/IN的发生率为每年0.4- 0.5%。多因素Logistic回归分析显示，年龄、男性、体重指数（BMI）、高尿酸血症、高血压、血脂异常与NS/IN相关。通过多因素Logistic回归分析，发现男性、高血压、BMI、吸烟4个因素显著相关，对40-74岁接受特定健康检查的熊本市民进行分析，发现除了高血压和年龄这两个重要因素外，男性和肥胖也是独立于高血压的NS/IS的危险因素。
Nephrosclerosis/ischemic nephropathy (NS/IN) ranks third among renal diseases requiring dialysis in Japan. Although it is an important renal disease in terms of frequency, its prevalence, new incidence, and risk factors are not fully elucidated.We analyzed the prevalence, incidence, concurrent diseases, and risk factors of NS/IN by using data from specific health checkups of Kumamoto citizens between 2008 and 2010.Although the prevalence of NS/IN was 1-2 % in people in their 40s, it increased sharply with age, reaching 17.6 % in people aged 70-74 years. The incidence of new NS/IN was 0.4-0.5 % per year. In multivariate logistic regression analysis, factors such as age, male gender, body mass index (BMI), hyperuricemia, hypertension, and dyslipidemia correlated with NS/IN. When risk factors associated with NS/IN progress were evaluated by multivariate logistic regression analysis, four factors-male gender, hypertension, BMI, and current smoking-significantly correlated.The analysis of Kumamoto citizens aged 40-74 years receiving specific health checkups showed that in addition to hypertension and age that were considered important, male gender and obesity are also risk factors for NS/IS independent from hypertension.