Long-Term Exercise Training Attenuates Age-Related Diastolic Dysfunction: Association of Myocardial Collagen Cross-Linking
Long-Term Exercise Training Attenuates Age-Related Diastolic Dysfunction: Association of Myocardial Collagen Cross-Linking
复制标题
DOI：
10.3346/jkms.2009.24.1.32
复制
发表时间：
2009-02-01
影响因子：
4.5
通讯作者：
Kim, Mi-Hyang
中科院分区：
文献类型：
--
作者：
Choi, Su-Yeon;Chang, Hyuk-Jae;Kim, Mi-Hyang
舒张性心力衰竭的发病率随着年龄的增长而急剧增加。我们调查了长期运动训练对年龄相关性舒张功能障碍的影响。老龄（25月龄）雄性Fischer 344大鼠在12周的跑步机运动训练或久坐笼生活后进行研究（每组N=7）。我们使用压力-容量传导导管和磁共振成像来测定心脏性能。测定胶原体积分数（CVF）和心肌胶原溶解度作为晚期糖基化终产物（AGEs）交联胶原的指标。训练组患者收缩压增量最大斜率（+dP/dt）和收缩压-容积关系斜率较高，舒张末期容积（EDV）、δ EDV （EDV增量至基线EDV的百分比）和舒张末期压力-容积关系斜率较低。舒张压衰减最大斜率（-dP/dt）和左室压衰减时间常数（tau）无显著差异。运动训练减少了AGEs交联胶原蛋白，而不是CVF。长期运动训练似乎可以减轻与年龄相关的心脏收缩功能和心肌硬度的恶化，并可以减少心肌中病理性AGEs交联胶原蛋白的含量。
The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using a pressure-volume conductance catheter and magnetic resonance imaging. Collagen volume fraction (CVF) and myocardial collagen solubility by pepsin as an index of advanced glycation end products (AGEs) crosslinked collagen were measured. The maximal slope of systolic pressure increment (+dP/dt) and the slope of end-systolic pressure-volume relation were higher, and end diastolic volume (EDV), Delta EDV (the percentage of the EDV increment-to-baseline EDV) and the slope of end-diastolic pressure-volume relation were lower in training group. The maximal slope of diastolic pressure decrement (-dP/dt) and time constant of LV pressure decay (tau) had no difference. AGEs cross-linked collagen, not CVF was reduced by exercise training. Long-term exercise training appears to attenuate age-related deterioration in cardiac systolic function and myocardial stiffness and could be reduce in pathologic AGEs cross-linked collagen in myocardium.