The relation of White Matter Hyperintensities to implicit learning in healthy older adults
The relation of White Matter Hyperintensities to implicit learning in healthy older adults
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DOI：
10.1002/gps.685
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发表时间：
2002-07-01
影响因子：
4
通讯作者：
DeKosky, ST
中科院分区：
文献类型：
--
作者：
Aizenstein, HJ;Nebes, RD;DeKosky, ST
目的探讨脑血管疾病表现为脑白质高信号的磁共振证据是否与正常老年志愿者的内隐序列学习成绩下降有关。方法对108名社区老年人进行磁共振成像检查，并执行一项隐式序列学习任务--系列反应时任务。这种关联与深部白质和脑室周围改变都有关系。影响SRT成绩的其他因素(基线反应时和转换成本)与WMH的存在没有显著相关。结论WMH除了与先前发现的广泛性认知缺陷有关外，还与序列内隐学习的具体下降有关。版权所有(C)2002 John Wiley Sons，Ltd.
Objective This study examined whether MRI evidence of cerebrovascular disease in the form of white matter hyperintensities (WMH) was associated with decreased implicit sequence learning performance in a high-functioning group of normal elderly volunteers.Method One hundred and eight community-dwelling elderly individuals received an MRI and performed an implicit sequence learning task, the serial reaction time (SRT) task.Results Hyperintensities present in the white matter were associated with a decreased learning effect. This association was found with both deep white matter and periventricular changes. Other factors affecting SRT performance (i.e., baseline reaction time and switch-cost) were not significantly related to the presence of WMH.Conclusions The results indicate that in addition to previously identified generalized cognitive deficits, WMH are also associated with a specific decrease in the implicit learning of sequences. Copyright (C) 2002 John Wiley Sons, Ltd.