The Generation and Regulation of Tissue-Resident Tregs and Their Role in Autoimmune Diseases
The Generation and Regulation of Tissue-Resident Tregs and Their Role in Autoimmune Diseases
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组织驻留调节性T细胞的产生和调节及其在自身免疫性疾病中的作用
DOI：
10.1155/2020/8815280
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发表时间：
2020
影响因子：
4.1
通讯作者：
Yi Li
中科院分区：
文献类型：
--
作者：
Shuang Wang;Xueyang Zou;Yi Zhang;Xiaoya Wang;Wei Yang;Yi Li
调节性T细胞（Regulatory T cells，Tcells）作为T细胞的重要亚群，通过调节免疫应答和预防自身免疫性疾病，在维持机体内环境稳定中发挥重要作用。深入研究发现，Tcl4具有很强的不稳定性和可塑性，根据其发育来源，Tcl4可分为胸腺源性Tcl4（tTcl4）、内源性诱导性Tcl4（pTcl4）和诱导性Tcl4（iTcl4），前者是由抗原刺激的外周T细胞在体内产生，后者是由幼稚T细胞在体外分化而来。近年来，研究发现，根据其所在部位，THBE分为淋巴和组织驻留THBE。对淋巴组织TdR的产生和功能的研究已经比较全面和深入，但对组织TdR的作用仍处于探索阶段，已成为研究热点。本文综述了TdR的不稳定性和可塑性，以及TdR在生物学领域的最新研究进展，包括脂肪组织、结肠、骨骼肌和最近发现的其他TdR，以及它们在特定组织中的产生、调节和功能，以及它们在自身免疫性疾病发病机制中的作用。
Regulatory T cells (Tregs), as an important subset of T cells, play an important role in maintaining body homeostasis by regulating immune responses and preventing autoimmune diseases. In-depth research finds that Tregs have strong instability and plasticity, and according to their developmental origin, Tregs can be classified into thymic-derived Tregs (tTregs), endogenous-induced Tregs (pTregs), which are produced by antigen-stimulated T cells in the periphery in vivo, and induced Tregs (iTregs), which differentiate from naïve T cells in vitro. In recent years, studies have found that Tregs are divided into lymphatic and tissue-resident Tregs according to their location. Research on the generation and function of lymphoid Tregs has been more comprehensive and thorough, but the role of tissue Tregs is still in the exploratory stage, and it has become a research hot spot. In this review, we discuss the instability and plasticity of Tregs and the latest developments of tissue-resident Tregs in the field of biology, including adipose tissue, colon, skeletal muscle, and other Tregs that have been recently discovered as well as their production, regulation, and function in specific tissues and their role in the pathogenesis of autoimmune diseases.
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影响因子：
32.4
作者：
Bailey-Bucktrout, Samantha L.;Martinez-Llordella, Marc;Zhou, Xuyu;Anthony, Bryan;Rosenthal, Wendy;Luche, Herve;Fehling, Hans J.;Bluestone, Jeffrey A.
通讯作者：
Bluestone, Jeffrey A.
影响因子：
29
作者：
Kolodin D;van Panhuys N;Li C;Magnuson AM;Cipolletta D;Miller CM;Wagers A;Germain RN;Benoist C;Mathis D
通讯作者：
Mathis D
影响因子：
32.4
作者：
Scharschmidt TC;Vasquez KS;Truong HA;Gearty SV;Pauli ML;Nosbaum A;Gratz IK;Otto M;Moon JJ;Liese J;Abbas AK;Fischbach MA;Rosenblum MD
通讯作者：
Rosenblum MD
影响因子：
32.4
作者：
Kuswanto W;Burzyn D;Panduro M;Wang KK;Jang YC;Wagers AJ;Benoist C;Mathis D
通讯作者：
Mathis D
影响因子：
20.3
作者：
Beriou, Gaelle;Costantino, Cristina M.;Hafler, David A.
通讯作者：
Hafler, David A.