Interactions of platelets, blood-borne tissue factor, and fibrin during arteriola thrombus formation in vivo
Interactions of platelets, blood-borne tissue factor, and fibrin during arteriola thrombus formation in vivo
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DOI：
10.1080/10739680590925682
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发表时间：
2005-04-01
期刊：
影响因子：
2.4
通讯作者：
Furie, B
中科院分区：
文献类型：
--
作者：
Sim, DS;Flaumenhaft, R;Furie, B
血管损伤后的血栓形成是止血和病理性血管闭塞的重要组成部分。这个过程发生在封闭的加压环境中，血液在受伤部位快速流动。血栓形成必须迅速发生以减少失血，但要仔细调节以限制血管闭塞。循环细胞、血浆蛋白、血管壁成分和物理力（例如剪切力）都会影响血栓的形成。历史上，血栓形成是通过分离血液中参与凝块形成的不同成分来研究的。随着光学技术的改进，研究人员越来越多地在视频显微镜下研究血栓形成，作者研究了转基因小鼠、骨髓移植小鼠和接受调节血栓形成药物治疗的小鼠血栓形成过程中血小板、纤维蛋白和组织因子在损伤部位的动力学和沉积的变化。这些小鼠中血栓各种成分积累动力学的差异为小动脉中血栓形成提供了新的见解。本综述讨论了血小板细胞内信号传导的作用。 P-选择素在血小板和血栓形成过程中携带组织因子的微粒上的表达。
Thrombus formation following vascular injury is an essential component of both hemostasis and pathologic vessel occlusion. This process occurs in a closed, pressurized environment in which blood flows rapidly over the injury site. Thrombus formation must occur quickly to reduce blood loss, but is carefully modulated to limit vessel occlusion. Circulating cells, plasma proteins, vessel wall components, and physical forces such as shear all influence thrombus formation. Historically, thrombus formation has been studied by isolating the separate components of blood involved in clot formation. With improved optical techniques, investigators have increasingly studied thrombus formation under videomicroscopy, the authors have studied the changes in the kinetics and deposition of platelets, fibrin, and tissue factor at the injury site during thrombosis in transgenic mice, bone marrow transplanted mice, and mice treated with pharmacological agents that modulate thrombosis. The differences in the kinetics of accumulation of the various components of thrombus in these mice have provided new insights about thrombus formation in arterioles. This review discusses the role of platelet intracellular signaling. P-selectin expression on platelets, and tissue factor-bearing microparticles in thrombus formation.