A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos
A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos
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DOI：
10.1016/j.trstmh.2004.08.007
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发表时间：
2005-06-01
影响因子：
2.2
通讯作者：
Newton, PN
中科院分区：
文献类型：
--
作者：
Phongmany, S;Phetsouvanh, R;Newton, PN
我们对老挝万象的 50 名经培养确诊为无并发症伤寒的成人进行了一项随机开放试验，分别口服氯霉素（50 mg/kg/天，分四次服用，持续 14 天）与氧氟沙星（15 mg/kg/天，分两次服用，持续 3 天）。患者患病的中位时间（范围）为 8 (2-30) 天。所有肠沙门氏菌血清型伤寒分离株均对萘啶酸敏感，其中四种（8%）对氯霉素耐药，三种（6%）对多种药物耐药。氯霉素组的中位退烧时间（范围）为 90（24-224）小时，氧氟沙星组为 54（6-93）小时（P < 0.001）。氯霉素组的一名患者出现回肠穿孔。对于伤寒住院治疗，无论抗生素敏感性如何，三天氧氟沙星比 14 天氯霉素更有效，并且费用相似。 (c) 2005 年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
We conducted a randomized open trial of oral chloramphenicol (50 mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P < 0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost. (c) 2005 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.