Direct Determination of Absolute Molecular Stereochemistry in Gas Phase by Coulomb Explosion Imaging
Direct Determination of Absolute Molecular Stereochemistry in Gas Phase by Coulomb Explosion Imaging
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DOI：
10.1126/science.1240362
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发表时间：
2013-09-06
期刊：
影响因子：
56.9
通讯作者：
Schoeffler, Markus S.
中科院分区：
文献类型：
--
作者：
Pitzer, Martin;Kunitski, Maksim;Schoeffler, Markus S.
Bijvoet的方法利用了反常的X射线衍射或色散，是直接确定分子绝对（立体化学）构型的标准方法，但它需要晶体样品，并且通常在仅包含轻原子的结构中具有挑战性。在这里，我们展示了一种质谱方法，直接图像的绝对配置的单个分子在气相中的冷靶反冲离子动量谱激光电离诱导库仑爆炸后。该技术适用于典型的手性分子溴氯氟甲烷和同位素手性甲烷衍生物溴二氯甲烷。
Bijvoet's method, which makes use of anomalous x-ray diffraction or dispersion, is the standard means of directly determining the absolute (stereochemical) configuration of molecules, but it requires crystalline samples and often proves challenging in structures exclusively comprising light atoms. Herein, we demonstrate a mass spectrometry approach that directly images the absolute configuration of individual molecules in the gas phase by cold target recoil ion momentum spectroscopy after laser ionization-induced Coulomb explosion. This technique is applied to the prototypical chiral molecule bromochlorofluoromethane and the isotopically chiral methane derivative bromodichloromethane.