Neonatal development of projections from the basolateral amygdala to prefrontal, striatal, and thalamic structures in the rat
Neonatal development of projections from the basolateral amygdala to prefrontal, striatal, and thalamic structures in the rat
复制标题
DOI：
10.1002/cne.10084
复制
发表时间：
2002-01-14
影响因子：
2.5
通讯作者：
Van Ree, JM
中科院分区：
文献类型：
--
作者：
Bouwmeester, H;Wolterink, G;Van Ree, JM
最近，开发了神经发育障碍的动物模型。在此模型中，将早期新生儿（出生后第 7 天 [Pd 7]）基底外侧杏仁核病变的影响与晚年病变（Pd 21）的影响进行比较。报告的数据表明，杏仁核在生命早期特定时间点的损伤会导致持久的行为障碍，这种障碍在青春期后变得更加明显，例如，只有早期损伤才会导致前脉冲抑制的破坏，这在精神分裂症患者中也观察到。因此，推测早期损伤可能会影响神经解剖学和神经化学组织以及其他大脑结构的功能。这是通过使用顺行示踪剂生物素化葡聚糖胺和菜豆-白细胞凝集素进行研究的。在新生儿第 7、9、11、13 和 26 天时，杏仁纤维尤其存在于丘脑内侧 (MDT)、伏隔核 (Acb) 和前额皮质 (PFC) 中。然而，与 PFC 相比，MDT 和 Acb 的杏仁核神经支配地形的发育明显不同。对于 MDT 和 Acb，在 Pd 7 和 Pd 26 之间没有观察到神经支配的重大变化，而 PFC 的神经支配从新生儿弥漫性（Pd 7 和 9）重组为受限模式（Pd 11、13 和 26）。此外，神经支配变为成人样的双层模式。这些数据提供了有关可能参与新生杏仁核损伤大鼠异常神经发育的电路的信息，这些大鼠已被提议作为神经发育精神病理障碍的动物模型。 J.Comp。内罗尔。 442:239-249, 2002, (C) 2001 Wiley-Liss, Inc.
Recently, an animal model for neurodevelopmental disorders has been developed. In this model, the effects of an early neonatal (postnatal day 7 [Pd 7]) basolateral amygdala lesion are compared with the effects of a lesion later in life (Pd 21). The reported data indicate that amygdala damage at a specific point early in life results in enduring behavioral disturbances that become more manifest after puberty, for example, only an early lesion resulted in a disruption of the prepulse inhibition, which is also observed in people suffering from schizophrenia. Accordingly, it was postulated that the early damage may affect the neuroanatomic and neurochemical organization and functioning of other brain structures. This was studied by use of the anterograde tracers biotinylated dextran amine and Phaseolus vulgaris-leucoagglutinin. At neonatal days 7, 9, 11, 13, and 26, amygdaloid fibers were in particular present in the mediodorsal thalamus (MDT), nucleus accumbens (Acb), and prefrontal cortex (PFC). The development of the topography of the amygdaloid innervation, however, differed markedly for the MDT and Acb compared with the PFC. For the MDT and Acb, no major changes in innervation were observed between Pd 7 and Pd 26, whereas the innervation of the PFC reorganized from a neonatal diffuse (Pd 7 and 9) to a restricted pattern (Pd 11, 13, and 26). In addition, the innervation changed to an adult-like bilaminar pattern. These data provide information on the circuitry that may be involved in the aberrant neurodevelopment of neonatally amygdala-lesioned rats, which have been proposed as an animal model for neurodevelopmental psychopathological disorders. J. Comp. Neurol. 442:239-249, 2002, (C) 2001 Wiley-Liss, Inc.