A genetically caused embryonal ectodermal tumor in the mouse.
A genetically caused embryonal ectodermal tumor in the mouse.
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一种由基因引起的小鼠胚胎外胚层肿瘤。
DOI：
10.1093/jnci/48.1.141
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
D. Bennett
中科院分区：
文献类型：
--
作者：
K. Artzt;D. Bennett
这项研究的目的是确定影响分化过程的基因是否会产生异常分化的组织，同时也是恶性的。因此，通过移植到成年睾丸中来研究tw18/tw18胚胎过度生长的原条团的恶性潜力。 46 个 8 天 tw18/tw18 胚胎中有 15 个在移植超过 28 天后产生了组织学上的恶性生长，而其正常同窝胚胎的移植物则变成了良性畸胎瘤。恶性肿瘤类似于神经母细胞瘤或髓母细胞瘤，具有有限数量的外胚层衍生的畸胎瘤成分。还移植了一系列 7 天的胚胎，结果产生了 5 种恶性肿瘤，其特征是相同的增殖神经上皮。少数恶性肿瘤进行了二次移植，但由于免疫排斥或分化为成人型成熟外胚层衍生物而全部丢失。讨论了此类肿瘤的起源。
This study was conducted to determine whether a gene influencing the process of differentiation could produce an abnormally differentiated tissue that was at the same time malignant. Thus the malignant potential of the overgrown primitive streak mass oftw18/tw18embryos was investigated by their transplantation into adult testes. Fifteen of forty-six 8-daytw18/tw18embryos, when grafted for over 28 days, produced histologically malignant growths, whereas grafts of their normal littermates became benign teratomas. The malignant tumors resembled neuroblastomas or medulloblastomas with a limited number of ectodermally derived teratomatous elements. A series of 7-day embryos was also transplanted and 5 malignant tumors resulted that were characterized by the same proliferating neuroepithelium. A few malignancies were transplanted secondarily, but all were lost due to their immunological rejection or differentiation into adult-type mature ectodermal derivatives. A discussion of the origin of this type of tumor is presented.