Fabrication and nano-engineering of non-/noble metal-coupled plasmonic heterostructures for ultrasensitive photoelectrochemical immunoassays.
Fabrication and nano-engineering of non-/noble metal-coupled plasmonic heterostructures for ultrasensitive photoelectrochemical immunoassays.
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DOI：
10.1016/j.aca.2023.341472
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发表时间：
2023-06
影响因子：
6.2
通讯作者：
Xingxing Meng;Tianxiang Hang;Huiyang Zhou;Zongrui Zhang;Chuanping Li
中科院分区：
文献类型：
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作者：
Xingxing Meng;Tianxiang Hang;Huiyang Zhou;Zongrui Zhang;Chuanping Li
为了实现PEC生物分析中疾病标志物的可靠和超灵敏检测，理想的光电极和信号转导策略的构建和纳米工程是至关重要的。在此，非/贵金属耦合等离子体纳米结构（TiO 2/r-STO/Au）的战术设计具有高效的PEC性能。DFT和FDTD计算表明，还原SrTiO 3（r-STO）中的局域电荷充分增加并离域，从而支持局域表面等离子体共振。在等离子体激元r-STO和AuNPs的协同偶联作用下，发现TiO 2/r-STO/Au的PEC性能显著提高，起始电位降低。这一优点支持了TiO 2/r-STO/Au作为一种通过所提出的析氧反应介导的信号转导策略的自供电免疫分析。随着目标生物分子（PSA）的增加，TiO 2/r-STO/Au的催化活性位被阻断，导致氧评价反应的降低。在最佳条件下，免疫分析表现出优异的检测性能，检测限低至1.1 fg/mL。这项工作提出了一种新型的等离子体纳米材料的超灵敏PEC生物分析。
To achieve reliable and ultrasensitive detection for disease markers in PEC bioanalysis, constructing and nano-engineering of ideal photoelectrodes and signal transduction strategies are of vital importance. Herein, a non-/noble metal coupled plasmonic nanostructure (TiO2/r-STO/Au) was tactically designed with high-efficient PEC performance. Evidenced by the DFT and FDTD calculations, the reduced SrTiO3(r-STO) was found to support the localized surface plasmon resonance due to the sufficiently increased and delocalized local charge in r-STO. Under the synergistic coupling of plasmonic r-STO and AuNPs, the PEC performance of TiO2/r-STO/Au was found remarkably promoted with reduced onset potential. This merit supported TiO2/r-STO/Au as a self-powered immunoassay via a proposed oxygen-evolution-reaction mediated signal transduction strategy. With the increase of the target biomolecules (PSA), the catalytic active sites of TiO2/r-STO/Au would be blocked and result in the decrease of the oxygen evaluation reaction. Under optimal conditions, the immunoassays exhibited an excellent detection performance with a LOD as low as 1.1 fg/mL. This work proposed a new type of plasmonic nanomaterial for ultrasensitive PEC bioanalysis.