Fasting blood glucose: An underestimated risk factor for cardiovascular death - Results from a 22-year follow-up of healthy nondiabetic men
Fasting blood glucose: An underestimated risk factor for cardiovascular death - Results from a 22-year follow-up of healthy nondiabetic men
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DOI：
10.2337/diacare.22.1.45
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发表时间：
1999-01-01
期刊：
影响因子：
16.2
通讯作者：
Thaulow, E
中科院分区：
文献类型：
--
作者：
Bjornholt, JV;Erikssen, G;Thaulow, E
目的 - 由于现有的流行病学数据相互矛盾，我们调查了空腹血糖作为非糖尿病男性心血管死亡危险因素的可能影响。本研究报告了一项为期 22 年的关于空腹血糖作为心血管死亡预测因素的前瞻性研究的结果。 研究设计和方法 - 在 1,998 名表面健康的非糖尿病男性（年龄 40-59 岁）中，共有 1,973 名空腹血糖为 85 mg/dl），与最低的三个四分位数的人相比，心血管疾病死亡率显着更高。即使在调整了年龄、吸烟习惯、血脂、血压、1秒用力呼气量和身体素质（Cox模型）后，空腹血糖>85 mg/dl的男性心血管死亡的相对风险仍然为1.4（95% CI 1.04-1.8）。非心血管死亡与空腹血糖水平无关。结论——正常范围上限的空腹血糖值：似乎是表面健康的非糖尿病中年男性心血管死亡的重要独立预测因子。
OBJECTIVE - Because of the available conflicting epidemiological data, we investigated the possible impact of fasting blood glucose as a risk factor for cardiovascular death in nondiabetic men. This study reports the results from a 22-year prospective study on fasting blood glucose as a predictor of cardiovascular death.RESEARCH DESIGN AND METHODS - Of the 1,998 apparently healthy nondiabetic men (aged 40-59 years), a total of 1,973 with fasting blood glucose 85 mg/dl) had a significantly higher mortality rate from cardiovascular diseases compared with those in the three lowest quartiles. Even after adjusting for age, smoking habits, serum lipids, blood pressure, forced expiratory volume in 1 s, and physical fitness (Cox model), the relative risk of cardiovascular death for men with fasting blood glucose >85 mg/dl remained 1.4 (95% CI 1.04-1.8). Noncardiovascular deaths were unrelated to fasting blood glucose level.CONCLUSIONS - Fasting blood glucose values in. the upper normal range:appears to be an important independent predictor of cardiovascular death in nondiabetic apparently healthy middle-aged men.