Pubescenosides Q-R, two new phenolic glycosides from Ilex pubescens
Pubescenosides Q-R, two new phenolic glycosides from Ilex pubescens
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DOI：
10.14132/j.cnki.1673-5439.2020.06.001
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发表时间：
2020-03-11
影响因子：
1.7
通讯作者：
Wu, Peng
中科院分区：
文献类型：
--
作者：
Chen, Fang;Huang, Shi-Yun;Wu, Peng
从传统药材短尾绿根乙醇提取物中分离得到2个新的酚类苷（1-2）和6个现有化合物（3-8）。这些结构通过HR-ESI-MS， IR， UV和NMR（包括1d， 2d -NMR）进行了测定。研究了3种酚苷（1-3）对人HepG2细胞株的抗炎作用。结果表明，化合物3可通过nrf2介导的途径诱导P-gp和BCRP的表达。
Two new phenolic glycosides (1-2), along with six existing compounds (3-8), were isolated from the ethanolic extract of Ilex pubescens roots, a traditional folk medicine. These structures were determined using HR-ESI-MS, IR, UV, and NMR (including 1 D, 2 D-NMR). The anti-inflammatory activities of three phenolic glycosides (1-3) were evaluated in the human HepG2 cell lines. The results showed that compound 3 could induce P-gp and BCRP expression through the Nrf2-mediated pathway.