Screening mammography use and chemotherapy among female stage II colon cancer patients: a retrospective cohort study.
Screening mammography use and chemotherapy among female stage II colon cancer patients: a retrospective cohort study.
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DOI：
10.1186/1472-6963-10-98
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发表时间：
2010-04-19
影响因子：
2.8
通讯作者：
McBean AM
中科院分区：
文献类型：
--
作者：
Yu X;McBean AM
虽然化疗不是美国国家指南对II期结肠癌的常规建议，但20-30%的患者接受了化疗。本研究调查了癌症诊断前筛查性乳腺X线检查与II期结肠癌老年女性患者化疗的相关性。使用监测、流行病学和最终结果（SEER）-医疗保险数据（1996-2002）对2910例年龄67-79岁的女性II期结肠癌患者进行回顾性队列研究。使用医疗保险索赔数据确定筛查乳房X线检查和化疗的使用。采用多因素Logistic回归和Kaplan-Meier曲线。约25%的女性老年患者接受化疗。化疗率从1996-1998年的22%上升到2001-2002年的26%。在调整了社会人口统计学变量、肿瘤特征和合并症的Charlson指数后，在癌症诊断前接受筛查性乳房X线检查的患者接受化疗的几率比未接受筛查性乳房X线检查的患者高28%（OR：1.28，95%CI：1.07-1.54）。那些先前做过乳房X光检查的人也比那些没有做过乳房X光检查的人更早接受化疗。此外，具有不利肿瘤特征的患者更有可能接受化疗。在癌症诊断前使用乳房X线检查与有利的肿瘤特征相关。尽管关于II期结肠癌化疗的使用存在争议，但女性老年患者仍以较高的比例接受化疗。我们的研究结果表明，病人的健康信念和寻求医疗保健的行为，以及医生的建议，在癌症治疗的决定发挥重要作用。
Although chemotherapy is not a routine recommendation for stage II colon cancer by the U.S. national guidelines, 20-30% of patients have received chemotherapy. This study investigated whether screening mammography use before the cancer diagnosis was associated with chemotherapy use among female elderly patients with stage II colon cancer. Retrospective cohort study on 2910 female stage II colon cancer patients aged 67-79 using the Surveillance, Epidemiology and End Results (SEER)-Medicare data (1996-2002). Screening mammography use and chemotherapy use were identified using Medicare claims data. Multivariate logistic regression and Kaplan-Meier curves were used. About 25% of female elderly patients received chemotherapy. The chemotherapy rates increased from 22% in 1996-1998 to 26% in 2001-2002. After adjusting for socio-demographic variables, tumor characteristics and Charlson index for comorbidities, the odds of receiving chemotherapy were 28% higher among those who had a screening mammogram before the cancer diagnosis than those who did not (OR: 1.28, 95% CI: 1.07-1.54). Those with a prior mammogram also received chemotherapy earlier than those without. In addition, patients with unfavorable tumor characteristics were more likely to receive chemotherapy. Mammography use before the cancer diagnosis was associated with favorable tumor characteristics. Despite the controversy about the chemotherapy use among stage II colon cancer, female elderly patients still received chemotherapy at a high rate. Our findings suggest that patient's health beliefs and health care seeking behavior, together with physician's recommendation, play important roles in the cancer treatment decision.
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影响因子：
10.3
作者：
Dobie, Sharon A.;Baldwin, Laura-Mae;Barlow, William
通讯作者：
Barlow, William
影响因子：
6.2
作者：
Hershman, Dawn;Hall, Michael J.;Neugut, Alfred I.
通讯作者：
Neugut, Alfred I.
影响因子：
7.2
作者：
DEYO, RA;CHERKIN, DC;CIOL, MA
通讯作者：
CIOL, MA
影响因子：
9.8
作者：
McBean, A. Marshall;Yu, Xinhua;Virnig, Beth A.
通讯作者：
Virnig, Beth A.
DOI：
10.1007/s11764-007-0037-7
发表时间：
2007-12-01
期刊：
Journal of cancer survivorship : research and practice
影响因子：
--
作者：
Yu, Xinhua;McBean, A Marshall;Virnig, Beth A
通讯作者：
Virnig, Beth A