Serum lipid concentration in relation to anthropometric indices of central and peripheral fat distribution in 20,021 British men and women: Results from the EPIC-Norfolk population-based cohort study
Serum lipid concentration in relation to anthropometric indices of central and peripheral fat distribution in 20,021 British men and women: Results from the EPIC-Norfolk population-based cohort study
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DOI：
10.1016/j.atherosclerosis.2005.12.027
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发表时间：
2006-12-01
期刊：
影响因子：
5.3
通讯作者：
Khaw, Kay-Tee
中科院分区：
文献类型：
--
作者：
Canoy, Dexter;Wareham, Nicholas;Khaw, Kay-Tee
目的：中心性肥胖与不良代谢特征（包括血脂异常）有关，但最近的研究表明，外周脂肪分布在调节循环非酯化脂肪酸的每日流量中发挥作用。我们研究是否血脂水平不同的中央和外周脂肪distribution在一般population.Methods和结果：我们研究了20,021明显健康的男性和女性的诺福克队列的欧洲调查癌症和营养（EPIC-诺福克）的脂肪分布指数和脂质浓度之间的横截面关系。无论男女，腰臀比与总胆固醇和低密度脂蛋白（LDL）胆固醇呈正相关，与高密度脂蛋白（HDL）胆固醇呈负相关，与体重指数（BMI）无关。虽然类似的结果，指出腰围，具有较大的臀围的个人有较低的总胆固醇和LDL-胆固醇和HDL-胆固醇较高时，调整BMI和/或腰围在男性和women.Conclusion：区域脂肪分布与血脂独立的BMI。腰围和臀围在相反方向上的独立贡献是有趣的。这些发现可能有助于解释不同脂肪分布表型与冠心病之间的相关性。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Aims: Central adiposity has been linked with adverse metabolic profile including dyslipidaemia but recent studies suggested that peripheral fat distribution play a role in regulating daily fluxes in circulating non-esterified fatty acids. We examine whether lipid levels vary between central and peripheral fat distribution in the general population.Methods and results: We examined the cross-sectional relation between fat distribution indices and lipid concentration in 20,021 apparently healthy men and women of the Norfolk cohort of the European Investigation into Cancer and Nutrition (EPIC-Norfolk). Waist-hip ratio was positively related to total and low density lipoprotein (LDL) cholesterol and negatively related to high density lipoprotein (HDL) cholesterol in both men and women, independently of body mass index (BMI). Although similar results were noted for waist circumference, individuals with bigger hip circumference had lower total and LDL-cholesterol and higher HDL-cholesterol when adjusting for BMI and/or waist circumference in both men and women.Conclusion: Regional fat distribution was related to lipid profile independently of BMI. The independent contribution of waist and hip circumference in opposite directions was intriguing. These findings may help explain the associations observed between different fat distribution phenotypes and coronary heart disease. (c) 2006 Elsevier Ireland Ltd. All rights reserved.