Changes in the Gastric Mucosa With Aging
Changes in the Gastric Mucosa With Aging
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DOI：
10.1016/j.cgh.2015.02.020
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发表时间：
2015-12-01
影响因子：
12.6
通讯作者：
Genta, Robert M.
中科院分区：
文献类型：
--
作者：
Sonnenberg, Amnon;Genta, Robert M.
背景与目的：我们的目的是描述年龄相关的变化，在胃粘膜和调查幽门螺杆菌感染的贡献，这些changes.METHODS：我们收集了数据，从一个大型的国家病理数据库的895,323例受试者进行食管胃镜检查与胃活检从2008年1月至2013年12月在内镜中心在美国各地。各种类型的胃组织病理学的患病率表示为总研究人群的百分比，分层的性别，年龄，和states.RESULTS：在一生中，胃粘膜变得异常的50%的受试者。在幽门螺杆菌感染率高的地区，有较高比例的人患有胃异常。在22%的活检中观察到幽门螺杆菌相关的慢性活动性胃炎和感染引起的粘膜变化;这些是观察到的最常见的胃异常。在18%的活检中检测到反应性胃病，随着年龄的增长而增加，是观察到的胃病理学的第二常见因素。结论：根据对美国食管胃十二指肠镜检查收集的活检的分析，胃部异常随着年龄的增长而增加。组织学分析发现的大多数病理条件是由幽门螺杆菌感染引起的，但许多其他原因尚不清楚。
BACKGROUND & AIMS: We aimed to characterize age-related changes in the gastric mucosa and investigate the contribution of Helicobacter pylori infection to these changes.METHODS: We collected data from a large national pathology database of 895,323 subjects who underwent esophagogastroduodenoscopy with gastric biopsies from January 2008 through December 2013 at endoscopy centers throughout the United States. The prevalence of various types of gastric histopathology was expressed as percent of the total study population, stratified by sex, age, and state.RESULTS: Over a lifetime, the gastric mucosa became abnormal in 50% of subjects. A higher proportion of people in areas with a high prevalence of H pylori infection acquired gastric abnormalities. H pylori-associated chronic active gastritis and mucosal changes caused by infection were observed in 22% of biopsies; these were the most common gastric abnormalities observed. Reactive gastropathy, which was detected in 18% of biopsies, increased with age and was the second most common factor of gastric pathology observed.CONCLUSIONS: On the basis of an analysis of biopsies collected by esophagogastroduodenoscopy in the United States, gastric abnormalities increase with age. Most pathologic conditions detected by histologic analysis are caused by H pylori infection, but the causes of many others are unknown.