The HSP Immune Network in Cancer.
The HSP Immune Network in Cancer.
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DOI：
10.3389/fimmu.2021.796493
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发表时间：
2021
影响因子：
7.3
通讯作者：
Mangasarova Y
中科院分区：
文献类型：
--
作者：
Albakova Z;Mangasarova Y
热休克蛋白是分子伴侣，其通过调节各种细胞过程来支持肿瘤的发展，所述细胞过程包括未折叠蛋白反应、线粒体生物能量学、细胞凋亡、自噬、坏死性凋亡、脂质代谢、血管生成、癌细胞干性、上皮-间充质转化和肿瘤免疫。除了细胞内活性外，热休克蛋白还具有不同的细胞外功能。然而，HSP分子伴侣在调节细胞内外免疫应答中的作用尚不清楚。在此，我们探讨热休克蛋白在肿瘤细胞内和细胞外的免疫功能。更广泛地了解热休克蛋白如何调节免疫反应可能为有效的免疫疗法的发展提供重要的见解。
Heat shock proteins are molecular chaperones which support tumor development by regulating various cellular processes including unfolded protein response, mitochondrial bioenergetics, apoptosis, autophagy, necroptosis, lipid metabolism, angiogenesis, cancer cell stemness, epithelial-mesenchymal transition and tumor immunity. Apart from their intracellular activities, HSPs have also distinct extracellular functions. However, the role that HSP chaperones play in the regulation of immune responses inside and outside the cell is not yet clear. Herein, we explore the intracellular and extracellular immunologic functions of HSPs in cancer. A broader understanding of how HSPs modulate immune responses may provide critical insights for the development of effective immunotherapies.