TRACKING AND PREDICTIVENESS OF SERUM-LIPID AND LIPOPROTEIN MEASUREMENTS IN CHILDHOOD - A 12-YEAR FOLLOW-UP - THE CARDIOVASCULAR RISK IN YOUNG FINNS STUDY
TRACKING AND PREDICTIVENESS OF SERUM-LIPID AND LIPOPROTEIN MEASUREMENTS IN CHILDHOOD - A 12-YEAR FOLLOW-UP - THE CARDIOVASCULAR RISK IN YOUNG FINNS STUDY
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DOI：
10.1093/oxfordjournals.aje.a117210
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发表时间：
1994-12-15
影响因子：
5
通讯作者：
AKERBLOM, HK
中科院分区：
文献类型：
--
作者：
PORKKA, KVK;VIIKARI, JSA;AKERBLOM, HK
作者分析了芬兰儿童和年轻人在12年随访期内血清脂质和脂蛋白测量的跟踪和预测性。1980年，对3,596名3-18岁健康受试者的代表性样本进行了检查。随访研究分别于1983年、1986年、1989年和1992年进行。可获得关于血脂和脂蛋白、人体测量、饮食和吸烟习惯以及口服避孕药使用情况的数据。1980年和1992年有883例受试者（47%为男性）的完整血脂数据，他们构成了本分析的研究队列。在研究的每个血脂变量中发现了显著的跟踪。血清总胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇、LDL：HDL胆固醇比值和甘油三酯的12年相关性范围分别为0.48-0.58、0.53 - 0.58、0.53 - 0.58、0.57-0.59和0.33-0.37。男性比女性表现出更多的跟踪;没有明确的年龄趋势。HDL胆固醇的跟踪优于HDL（3）胆固醇（分别为0.64 vs. 0.43; 3年跟踪）。载脂蛋白A-1和B分别与HDL和LDL胆固醇相比显示出相似的跟踪量。大约50%的受试者最初落入总胆固醇、LDL胆固醇和HDL胆固醇的极端五分位数，12年后处于相同的五分位数。在多元回归分析中，儿童肥胖、运动、饮食和吸烟习惯对成人血脂值的预测没有明显的帮助。然而，使用两个儿童测量增加了成人血脂变异的解释。虽然普遍筛查不能被认可，这些发现强调了血脂测量在早期发现常见脂蛋白紊乱和在儿童冠心病风险的初步评估中的重要性。
The authors analyzed tracking and predictiveness of serum lipid and lipoprotein measurements in Finnish children and young adults over a 12-year follow-up period. A representative sample of 3,596 healthy subjects aged 3-18 years was examined in 1980. The follow-up studies were done in 1983, 1986, 1989, and 1992. Data were available on serum lipids and lipoproteins, anthropometric measurements, dietary and smoking habits, and use of oral contraceptives. Complete data on serum lipids in 1980 and 1992 were available for 883 subjects (47% males), and they comprised the study cohort for this analysis. Significant tracking was found in each of the serum lipid variables studied. The range of 12-year correlations was 0.48-0.58, 0.53-0.58, 0.53-0.58, 0.57-0.59, and 0.33-0.37 for serum total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, the LDL:HDL cholesterol ratio, and triglycerides, respectively. Males showed more tracking than females; there was no clear age trend. Tracking of HDL, cholesterol was better than that of HDL(3) cholesterol (0.64 vs. 0.43, respectively; 3-year tracking). Apolipoproteins A-l and B showed similar amounts of tracking compared with HDL and LDL cholesterol, respectively. Approximately 50% of subjects who initially fell into the extreme quintiles of total cholesterol, LDL cholesterol, and HDL cholesterol were in the same quintiles after 12 years. In multiple regression analyses, childhood obesity, exercise, diet, and smoking habits did not markedly aid the prediction of adult serum lipid values. However, the use of two childhood measurements increased the amount of adult serum lipid variability explained. Although universal screening cannot be endorsed, these findings emphasize the importance of serum lipid measurements in the early detection of familiar lipoprotein disorders and in the initial evaluation of coronary heart disease risk in childhood.