CONNECTIONAL TOPOGRAPHY IN THE ZEBRAFISH OLFACTORY SYSTEM - RANDOM POSITIONS BUT REGULAR SPACING OF SENSORY NEURONS PROJECTING TO AN INDIVIDUAL GLOMERULUS
CONNECTIONAL TOPOGRAPHY IN THE ZEBRAFISH OLFACTORY SYSTEM - RANDOM POSITIONS BUT REGULAR SPACING OF SENSORY NEURONS PROJECTING TO AN INDIVIDUAL GLOMERULUS
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DOI：
10.1073/pnas.91.24.11646
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发表时间：
1994-11-22
影响因子：
11.1
通讯作者：
KORSCHING, S
中科院分区：
文献类型：
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作者：
BAIER, H;ROTTER, S;KORSCHING, S
目前还不清楚嗅觉系统中的神经元连接是如何指定的。为了定义在这个系统中的连接规则，我们调查了感觉神经元从嗅上皮到嗅球的投射是否是拓扑有序的。用1，1 ′-双十八烷基3，3，3 ′，3 ′-四甲基吲哚羰花青高氯酸盐（DiI）进行反向追踪，发现投射到单个肾小球的神经元广泛分布于嗅上皮。它们在感觉表面的位置不能预测它们的肾小球特异性，可能是随机的。统计分析表明，连接到同一肾小球的神经元彼此之间的距离为几个细胞直径。神经元广泛而均匀地分布在感觉表面，它们投射到目标区域的一个点上，这构成了一种不寻常的连接拓扑结构，与其他感觉系统中的精确拓扑（邻域保留）图形成了鲜明对比。它可以最大限度地检测到激活单个肾小球单位的气味的可能性。
It is unknown how neuronal connections are specified in the olfactory system. To define rules of connectivity in this system, we investigated whether the projection of sensory neurons from the olfactory epithelium to the olfactory bulb is topographically ordered. By backtracing with 1,1'-dioctadecyl 3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI), we find that neurons projecting into a single identified glomerulus are widely dispersed over the olfactory epithelium. Their positions in the sensory surface do not predict their glomerulus specificity and are probably random. A statistical analysis reveals that neurons connected to the same glomerulus are spaced at distances of several cell diameters from each other. The convergence of projections to one point in the target area from neurons that are widely and evenly distributed in the sensory surface constitutes an unusual type of connectional topography that contrasts with the precise topological (neighborhood-preserving) maps found in other sensory systems. It may maximize the probability to detect odorants that activate a single glomerular unit.