Circadian Activity Rhythm of the Deer Mouse, Peromyscus: Effect of Deuterium Oxide
Circadian Activity Rhythm of the Deer Mouse, Peromyscus: Effect of Deuterium Oxide
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鹿鼠（Peromyscus）的昼夜节律活动：氧化氘的影响
DOI：
10.1126/science.160.3831.1011
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发表时间：
1968
期刊：
影响因子：
56.9
通讯作者：
K. S. Rawson
中科院分区：
文献类型：
--
作者：
R. B. Suter;K. S. Rawson
脊椎动物活动节律（Peromyscus leucopus noveboracensis 的昼夜节律（大约 24 小时））的化学修饰已得到证实。使用转轮的活动来测量在持续黑暗的条件下单独饲养的小鼠的节律。饮用水中存在氧化氘。随着氧化氘浓度的增加，节律周期的长度直接线性增加。这种效应没有阈值，氧化氘的最大浓度（30%）导致昼夜节律周期延长 6%。从饮用水中去除氧化氘后，小鼠的节律恢复到与对照值相似的周期长度。
Chemical modification of a vertebrate activity rhythm, the circadian (approximately 24-hour) rhythm of Peromyscus leucopus noveboracensis, has been demonstrated. Activity in a running wheel was used to measure the rhythms of mice kept individually in conditions of continuous darkness. Deuterium oxide was presented in the drinking water. The length of the periods of rhythm increased directly and linearly with the increase in concentration of deuterium oxide. There is no threshold for this effect, and the maximum concentration of deuterium oxide (30 percent) that was presented resulted in a 6 percent lengthening of the period of circadian rhythm. The mice reverted to rhythms similar in period length to control values after deuterium oxide was withdrawn from their drinking water.