Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii
Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii
复制标题
杠柳和杠柳中的免疫抑制孕烷苷
DOI：
10.1016/j.phytochem.2008.08.015
复制
发表时间：
2008-11-01
期刊：
影响因子：
3.8
通讯作者：
Zhao, Weimin
中科院分区：
文献类型：
--
作者：
Feng, Jiaquan;Zhang, Rujun;Zhao, Weimin
从杠柳根皮中分得9个糖基含过氧官能团的甾烷苷（1-5和11-14）、5个寡糖（6-10）、6个甾烷苷（1 - 5 -20）和5个强心苷（21-25）。（萝摩科）和香加皮（Periploca forrestii Schltr.（萝摩科），两种用于治疗类风湿性关节炎的中药。其中，1-8是迄今未知的。它们的结构进行了表征的光谱分析的基础上。在药理学试验中，发现化合物1-5和11-14在体外表现出对T淋巴细胞增殖的抑制活性，IC 50值为0.29 μ M至1.97 μ M，而其它组分没有显示出显著的抑制活性。(C)2008爱思唯尔有限公司保留所有权利。
Nine pregnane glycosides containing peroxy functions in their sugar moieties (1-5 and 11-14), five oligosaccharides (6-10), six pregnane glycosides (15-20), and five cardiac glycosides (21-25) were isolated from the root barks of Periploca sepium Bge. (Asclepiadaceae) and the roots of Periploca forrestii Schltr. (Asclepiadaceae), two traditional Chinese medicines used for the treatment of rheumatoid arthritis. Among them, 1-8 are hitherto unknown. Their structures were characterized on the basis of spectroscopic analyses. In pharmacological testing, compounds 1-5 and 11-14 were found to exhibit inhibitory activity against the proliferation of T lymphocyte in vitro with IC50 values ranging from 0.29 mu M to 1.97 mu M, while the other components showed no significant inhibitory activity. (C) 2008 Elsevier Ltd. All rights reserved.