Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158 Met genotype.
Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158 Met genotype.
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DOI：
10.1186/1471-244x-13-63
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发表时间：
2013-02-19
期刊：
影响因子：
4.4
通讯作者：
van Os J
中科院分区：
文献类型：
--
作者：
Arts B;Simons CJ;Drukker M;van Os J
双相情感障碍患者抗精神病药物的使用与认知功能之间存在负相关，这可能是通过特定大脑区域的多巴胺信号改变介导的，以及 COMT Val108/158Met 等基因序列变异的调节。研究了抗精神病药物的使用与 COMT Val108/158Met 基因型对双相情感障碍患者两年认知功能的相互作用。在 51 名双相情感障碍患者中检查了 COMT Val108/158Met 和抗精神病药物之间在综合认知测量方面的相互作用，这些患者在两年内以两个月为间隔进行了 12 次评估（379 次观察）。抗精神病药物和 Val 等位基因负载之间的相互作用对双相情感障碍患者的综合认知测量有显着的负面影响 (p<0.001)。抗精神病药物对双相情感障碍认知功能的负面影响可能通过 COMT Val 108/158 Met 基因型来调节，并具有 Val 等位基因负载的负面影响。如果重复，结果可能表明双相情感障碍中的药物遗传学相互作用。
There is a negative association between the use of antipsychotics and cognitive functioning in bipolar patients, which may be mediated by altered dopamine signaling in selected brain areas, and moderation thereof by genetic sequence variation such as COMT Val108/158Met. The interaction between antipsychotic drug use and the COMT Val108/158Met genotype on two-year cognitive functioning in bipolar patients was examined. Interaction between the COMT Val108/158Met and antipsychotics on a composite cognitive measure was examined in 51 bipolar patients who were assessed 12 times at two-monthly intervals over a period of two years (379 observations). There was a significant negative effect of the interaction between antipsychotic medications and Val allele load on the composite cognitive measure in bipolar patients (p < 0.001). The negative effects of antipsychotics on cognitive functioning in bipolar disorder may be moderated by the COMT Val 108/158 Met genotype, with a negative effect of Val allele load. If replicated, the results may be indicative of pharmacogenetic interactions in bipolar disorder.