COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSONS-DISEASE
COGNITIVE DEFICITS IN THE EARLY STAGES OF PARKINSONS-DISEASE
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DOI：
10.1093/brain/106.2.257
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发表时间：
1983-01-01
期刊：
影响因子：
14.5
通讯作者：
SMITH, E
中科院分区：
文献类型：
--
作者：
LEES, AJ;SMITH, E
已知的神经心理测试揭示了额叶损伤患者的异常，用来研究30名患有特发性帕金森病的轻度残疾、右撇子患者的认知功能。没有一名患者接受过治疗，所有患者的CT脑部扫描都正常。患有抑郁症或高缺血评分的患者被排除在研究之外，年龄匹配的对照组采用类似的选择标准。在WAIS和新成人阅读智商测试中，患者的一般智能功能没有损害，在认知评估和双选择再认记忆测试中也没有明显异常。然而，帕金森氏症患者在转移概念集方面有明显更大的困难，在改进的威斯康星卡片分类测试和本顿单词流利性测试中都产生了更多的持久性错误。这些微妙的认知困难可能是帕金森病精神僵硬和僵硬的基础，并可能归因于上行的多巴胺能中皮质边缘通路的破坏
Neuropsychological tests known to reveal abnormalities in patients with frontal lobe damage were used to explore cognitive function in 30 mildly disabled, right-handed patients with idiopathic Parkinson's disease. None of the patients had received treatment and all had normal CT brain scans. Patients with depression or high ischaemia scores were excluded from the study and similar selection criteria were used for the age-matched controls. No impairment of general intellectual function was found in the patients using the WAIS and New Adult Reading IQ tests and no abnormalities were apparent on cognitive estimates and two-choice Recognition Memory Tests. Patients with Parkinson's disease, however, had significantly greater difficulty in shifting conceptual sets and produced more perseverative errors on both the modified Wisconsin Card Sorting Test and Benton's Word Fluency Test. These subtle cognitive difficulties might underlie the mental inflexibility and rigidity of Parkinson's disease and could be attributed to destruction of the ascending dopaminergic meso-corticolimbic pathway