Depression Severity Over 27 Months in Adolescent Girls Is Predicted by Stress-Linked Cortical Morphology
Depression Severity Over 27 Months in Adolescent Girls Is Predicted by Stress-Linked Cortical Morphology
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DOI：
10.1016/j.biopsych.2019.04.027
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发表时间：
2019-11-15
影响因子：
10.6
通讯作者：
Perlman, Greg
中科院分区：
文献类型：
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作者：
Bartlett, Elizabeth A.;Klein, Daniel N.;Perlman, Greg
背景：有证据支持早期生活压力和创伤影响皮质发育并增加抑郁的脆弱性。然而，目前还不清楚是否共同的压力生活事件在社区居住的青少年有类似的后果皮质development.METHODS：共232青春期女孩（平均年龄15.29 +/- 0.65岁）进行了评估与压力生活事件时间表（半结构化面试的压力在过去的9个月），并进行了磁共振成像扫描。使用FreeSurfer 5.3.0进行基于全脑表面的形态测量。在成像和前瞻性的时间在三个9个月的后续任命使用清单的抑郁和焦虑症状II.结果：至少有一个紧张的生活事件，在90%的青少年参与者在9个月前成像进行了评估。近期生活压力负荷越大，左楔前叶和左中央后叶皮质厚度越小，左上级额叶和右下顶叶体积越小（多重比较校正后，所有p <0.05）。在控制先前烦躁的情况下，在成像后27个月，压力相关簇中的左楔前叶厚度显著预测烦躁（β = -.11，p = .004）。左楔前叶皮质厚度占17.0%的压力和烦躁情绪之间的关联为27个月后成像（β = 0.04，p = 0.05）。结论：一致的证据，从影像学研究的创伤暴露的青年和临床前压力模型，一个沉重的负担，最近的共同生活压力在社区居住的青春期女孩与改变额/顶叶皮质形态。压力相关的楔前叶皮质厚度代表了青少年抑郁症的候选前瞻性生物标志物。
BACKGROUND: Evidence supports the notion that early-life stress and trauma impact cortical development and increase vulnerability to depression. However, it remains unclear whether common stressful life events in community-dwelling adolescents have similar consequences for cortical development.METHODS: A total of 232 adolescent girls (mean age 15.29 +/- 0.65 years) were assessed with the Stressful Life Events Schedule (a semistructured interview of stressors in the previous 9 months) and underwent a magnetic resonance imaging scan. FreeSurfer 5.3.0 was used to perform whole-brain surface-based morphometry. Dysphoria was assessed at the time of imaging and prospectively at three 9-month follow-up appointments using the Inventory of Depression and Anxiety Symptoms II.RESULTS: At least one stressful life event was reported in 90% of the adolescent participants during the 9 months preceding imaging. Greater burden of recent life stress was associated with less left precuneus and left postcentral cortical thickness and smaller left superior frontal and right inferior parietal volume (all p < .05 after multiple comparisons correction). Left precuneus thickness in the stress-associated cluster significantly predicted dysphoria for 27 months after imaging controlling for prior dysphoria (beta= -.11, p = .004). Left precuneus cortical thickness accounted for 17.0% of the association between stress and dysphoric mood for 27 months after imaging (beta = .04, p = .05).CONCLUSIONS: Consistent with evidence from imaging studies of trauma-exposed youths and preclinical stress models, a heavy burden of recent common life stress in community-dwelling adolescent girls was associated with altered frontal/parietal cortical morphology. Stress-linked precuneus cortical thickness represents a candidate prospective biomarker of adolescent depression.