The anemia of renal failure.
The anemia of renal failure.
复制标题
肾功能衰竭引起的贫血。
DOI：
10.1001/archinte.1958.00260140158024
复制
发表时间：
1958
期刊：
影响因子：
--
通讯作者：
J. P. Dawson
中科院分区：
文献类型：
--
作者：
J. Desforges;J. P. Dawson
贫血与尿毒症之间的关联是惊人的。然而，正如人们对与肾脏疾病相关的体征和症状的实际发病机制知之甚少一样，这种综合征中贫血的发生机制也知之甚少。这些研究的目的是评估生产性和破坏性缺陷的相对重要性，并将它们与临床状态相关联。方法和材料 血红蛋白根据 Crosby 等人的方法进行测量。 1 网织红细胞采用干法计数，并表示为计数的 1000 个细胞的百分比。根据 Shen 2 的技术测量渗透脆性，并如前所述绘制和比较增量曲线。机械脆性通过 Shen 等人 4 的方法的修改进行测量，使用 35 rpm 的旋转和 13 cm 的半径。时间间隔从 90 到 270 分钟不等。
The association of anemia with uremia is a striking one. However, just as the actual pathogenesis of the signs and symptoms associated with renal disease is poorly understood, so also is the mechanism of development of anemia in this syndrome. It is the purpose of these investigations to evaluate the relative importance of productive and destructive defects and to correlate them with the clinical state. Methods and Materials Hemoglobin was measured according to Crosby et al. 1 Reticulocytes were counted by the dry method and expressed as per cent of the 1000 cells counted. Osmotic fragility was measured according to the technique of Shen 2 and increment curves plotted and compared as previously described. Mechanical fragility was measured by a modification of the method of Shen et al., 4 with use of rotation of 35 rpm and a radius of 13 cm. Time intervals varied from 90 to 270 minutes.