Cytokine genotyping in preeclampsia
Cytokine genotyping in preeclampsia
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DOI：
10.1111/j.1600-0897.2005.00341.x
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发表时间：
2006-02-01
影响因子：
3.6
通讯作者：
Mattar, R
中科院分区：
文献类型：
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作者：
Daher, S;Sass, N;Mattar, R
考虑到细胞因子参与子痫前期（PE）的发病机制，细胞因子基因多态性可能影响细胞因子的产生，我们的目的是研究PE与肿瘤坏死因子(TNF)- α(-308)、转化生长因子- β 1（+10; 25）、白细胞介素(IL)-10（-1082）、IL-6（-174）和干扰素- γ(+874)多态性的关系。研究方法对PE女性（56名白人和95名非白人女性）和无产科病理的女性（92名白人和97名非白人女性）进行基因分型。数据分析采用卡方检验或Fisher精确检验。我们对这些结果和其他实验室的结果进行了荟萃分析，分析了tnf - α多态性与PE之间的关系。结果我们观察到白种PE女性（PE: 5%；对照组(C): 15%, P = 0.02）中IL-10 -1082-G/G基因型的频率较低，与所有其他多态性无关联，包括tnf - α结果的荟萃分析。结论PE与IL-10-(1082)多态性相关，而与TNF-(308)多态性无关。在meta分析的基础上，我们确认需要更多的研究来评估细胞因子基因型在疾病中的作用。
ProblemConsidering that cytokines are involved in preeclampsia (PE) pathogenesis and that cytokine gene polymorphism may affect cytokine production, our purpose was to investigate the association of PE with tumor necrosis factor (TNF)-alpha (-308), transforming growth factor-beta 1 (+10; 25), interleukin (IL)-10 (-1082), IL-6 (-174), and interferon-gamma (+874) polymorphisms.Method of studyGenotyping was performed in women with PE (56 White and 95 non-White women) and in women without obstetric pathology (92 White and 97 non-White women). Data were analyzed by the chi-square or Fisher exact test. We performed a meta-analysis encompassing these and results from other laboratories on the association of TNF-alpha polymorphisms and PE.ResultsWe observed a lower frequency of the IL-10 -1082-G/G genotype in White women with PE (PE: 5%; Control (C): 15%, P = 0.02) and no association for all other polymorphisms, including meta-analysis of TNF-alpha results.ConclusionOur study suggests that PE is associated with IL-10-(1082) polymorphism but not with TNF-(308) polymorphism. On the basis of meta-analysis, we confirm the need for more studies for the evaluation of cytokine genotype in disease.