The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale.
The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale.
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DOI：
10.1016/j.actbio.2012.02.022
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发表时间：
2012-07
影响因子：
9.7
通讯作者：
Swain MV
中科院分区：
文献类型：
--
作者：
Bertassoni LE;Orgel JP;Antipova O;Swain MV
龋齿的预防和治疗是牙科领域面临的主要挑战。这种牙科疾病的现代管理的基础，估计影响到西方国家90%的成年人，依赖于合成聚合物生物材料和组成牙齿有机基质的纳米结构超分子组装体之间的超细相互作用。然而，研究表明，这种相互作用对目前树脂基牙科修复的长期前景造成了不利影响。在这里，我们回顾了牙本质的有机基质，牙齿结构的最大组成部分的纳米结构组织的识别进展，并强调有关方面低估了修复生物材料与牙本质基质的相互作用。我们提供了新的见解的层次组装的超分子结构的牙本质胶原纤维和它们的结构依赖于水分子的影响。其次，我们回顾了最近的证据，蛋白多糖参与组成的牙本质有机网络。最后，我们讨论了这些复杂组装的纳米结构与蛋白酶降解过程的关系，这些降解过程导致目前树脂基牙科牙体的耐久性较低。我们认为，这些复杂的组织和固有的水合有机结构可能会对目前的疏水性和可水解的牙科聚合物，建立与牙齿基质超细接触的临床前景的结构限制。
The prevention and treatment of dental caries are major challenges occurring in dentistry. The foundations for modern management of this dental disease, estimated to affect 90% of adults in Western countries, rest upon the dependence of ultrafine interactions between synthetic polymeric biomaterials and nanostructured supramolecular assemblies that compose the tooth organic substrate. Research has shown, however, that this interaction imposes less than desirable long-term prospects for current resin-based dental restorations. Here we review progress in the identification of the nanostructural organization of the organic matrix of dentin, the largest component of the tooth structure, and highlight aspects relevant to understating the interaction of restorative biomaterials with the dentin substrate. We offer novel insights into the influence of the hierarchically assembled supramolecular structure of dentin collagen fibrils and their structural dependence on water molecules. Secondly, we review recent evidence for the participation of proteoglycans in composing the dentin organic network. Finally, we discuss the relation of these complexly assembled nanostructures with the protease degradative processes driving the low durability of current resin-based dental restorations. We argue in favour of the structural limitations that these complexly organized and inherently hydrated organic structures may impose on the clinical prospects of current hydrophobic and hydrolyzable dental polymers that establish ultrafine contact with the tooth substrate.