Screening and evaluation of antioxidant activity of some 1,2,4-triazolo[1,5-a] quinazoline derivatives
Screening and evaluation of antioxidant activity of some 1,2,4-triazolo[1,5-a] quinazoline derivatives
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DOI：
10.4155/fmc-2017-0224
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发表时间：
2018-02-01
影响因子：
4.2
通讯作者：
Abuelizz, Hatem A.
中科院分区：
文献类型：
--
作者：
Al-Salahi, Rashad;Anouar, El-Hassane;Abuelizz, Hatem A.
目的：本研究旨在通过 1,1-二苯基-2-苦基肼自由基清除、三价铁还原抗氧化能力和还原能力测定来评估一系列新的三唑并喹唑啉 1-40 的抗氧化活性。结果：所有三唑并喹唑啉1-40均表现出从弱到中高的抗氧化活性。所得结果表明，三唑并喹唑啉30、36和38-40在所有化合物中具有优越性，作为合成抗氧化剂，与丁基羟基甲苯相比，其消耗1,1-二苯基-2-苦基肼和自由基的能力最高。结论：对目标的化学修饰和密度泛函理论研究为我们提供了一些有价值的澄清，使我们能够了解目标化合物对自由基更具活性所需的特性。
Aim: The present study was carried out to assess a new series of triazoloquinazolines 1-40 for their antioxidant activities using 1,1-diphenyl-2-picryl hydrazyl radical scavenging, ferric reduction antioxidant power and reducing power capability assays. Results: All triazoloquinazolines 1-40 exhibited antioxidant activity ranged from weak to moderate and high. The obtained findings revealed that the triazoloquinazolines 30, 36 and 38-40 have superiority among all compounds, demonstrating the highest capacity to deplete 1,1-diphenyl-2-picryl hydrazyl and free radicals, in relation to butylated hydroxyl toluene, as a synthetic antioxidant agent. Conclusion: Chemical modifications together with density functional theory study on the targets supplied us with some valuable clarifications about the required properties needed for the target compounds to be more active against free radicals.