Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease.
Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease.
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鼻内递送绕过靶向治疗剂到中枢神经系统并治疗神经退行性疾病的血脑屏障。
DOI：
10.1186/1471-2202-9-s3-s5
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发表时间：
2008-12-10
期刊：
影响因子：
2.4
通讯作者：
Frey WH 2nd
中科院分区：
文献类型：
--
作者：
Hanson LR;Frey WH 2nd
鼻内递送提供了绕过血脑屏障（BBB）以将治疗剂递送至脑和脊髓的实用的非侵入性方法。该技术允许不穿过BBB的药物在几分钟内被递送到中枢神经系统。它还可以直接将穿过BBB的药物输送到大脑，消除了全身给药的需要及其潜在的副作用。这是可能的，因为嗅觉和三叉神经在大脑和外部环境之间提供了独特的连接。鼻内递送不一定需要对治疗剂进行任何修饰。各种各样的治疗方法，包括小分子和大分子，都可以靶向受阿尔茨海默病影响的嗅觉系统和相关记忆区域。使用鼻内递送系统，研究人员已经逆转了阿尔茨海默病转基因小鼠模型的神经变性并挽救了记忆。鼻内胰岛素样生长因子-I、去铁胺和促红细胞生成素已被证明在动物模型中保护大脑免受中风。鼻内递送已被用于将神经保护肽NAP靶向脑以治疗神经变性。鼻内成纤维细胞生长因子-2和表皮生长因子已被证明刺激成年动物的神经发生。鼻内胰岛素可改善阿尔茨海默病或轻度认知障碍患者的记忆力、注意力和功能，甚至可改善正常成年人的记忆力和情绪。这种新的递送方法可以彻底改变阿尔茨海默病，中风和其他脑部疾病的治疗。
Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. It also directly delivers drugs that do cross the BBB to the brain, eliminating the need for systemic administration and its potential side effects. This is possible because of the unique connections that the olfactory and trigeminal nerves provide between the brain and external environment. Intranasal delivery does not necessarily require any modification to therapeutic agents. A wide variety of therapeutics, including both small molecules and macromolecules, can be targeted to the olfactory system and connected memory areas affected by Alzheimer's disease. Using the intranasal delivery system, researchers have reversed neurodegeneration and rescued memory in a transgenic mouse model of Alzheimer's disease. Intranasal insulin-like growth factor-I, deferoxamine, and erythropoietin have been shown to protect the brain against stroke in animal models. Intranasal delivery has been used to target the neuroprotective peptide NAP to the brain to treat neurodegeneration. Intranasal fibroblast growth factor-2 and epidermal growth factor have been shown to stimulate neurogenesis in adult animals. Intranasal insulin improves memory, attention, and functioning in patients with Alzheimer's disease or mild cognitive impairment, and even improves memory and mood in normal adult humans. This new method of delivery can revolutionize the treatment of Alzheimer's disease, stroke, and other brain disorders.