The Association Between Systemic Immune-Inflammation Index and Postoperative Cognitive Decline in Elderly Patients.
The Association Between Systemic Immune-Inflammation Index and Postoperative Cognitive Decline in Elderly Patients.
复制标题
老年患者全身免疫炎症指数与术后认知能力下降的关系
DOI：
10.2147/cia.s357319
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发表时间：
2022
影响因子：
3.6
通讯作者：
Bian, Jinjun
中科院分区：
文献类型：
--
作者：
Lu, Wenbi;Zhang, Keqin;Chang, Xinning;Yu, Xiya;Bian, Jinjun
关键词：
术后认知功能下降（POCD）在接受手术的老年患者中非常普遍。全身免疫炎症指数（SII）已被证明是许多炎症相关疾病的独立预测因子，但SII与POCD之间的关系尚不清楚。我们的目的是调查POCD和SII水平之间的关系，以检查SII在预测老年患者POCD中的潜力。本研究对我院骨科择期手术的老年患者进行了研究，并从入院时的血液样本中计算了SII、中性粒细胞/淋巴细胞比率（NLR）、单核细胞/淋巴细胞比率（MLR）。采用简易精神状态检查量表（MMSE）测定老年患者POCD。采用二项Logistic回归分析SII水平与POCD的关系。最终，76例患者中有19例（25%）被诊断为POCD。POCD患者入院时NLR、MLR、SII水平均显著高于非POCD患者，尤其是SII水平。Logistic回归分析显示SII与POCD的发生独立相关。受试者工作特征曲线分析表明，术前SII是POCD的显著预测因子，曲线下面积为0.909。提示术前血NLR、MLR、SII水平与POCD的发生有关。术前血清SII水平可作为老年骨科术后POCD的预后指标。SII在POCD中的应用价值有待于更多的临床研究进一步验证。
Postoperative cognitive decline (POCD) is highly prevalent in elderly patients who received surgery. The systemic immune-inflammation index (SII) has been shown to be an independent predictor of many diseases associated with inflammation, but the relationship between the SII and POCD is unknown. We aimed to investigate the association between POCD and SII levels to examine the potential of SII in predicting POCD in elderly patients. The present study was carried out among elderly patients who underwent elective orthopedics operation in our hospital, and SII, neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) were calculated from the admission blood sample. POCD was measured by Mini-mental State Examination (MMSE) in elderly patients. The association between SII levels and POCD was analyzed by binary logistic regression analysis. Finally, 19 (25%) of 76 patients were diagnosed with POCD. Compared with Non-POCD patients, POCD patients showed significantly higher levels of NLR, MLR, SII, especially SII at admission. SII was independently associated with the occurrence of POCD through the logistic regression analysis. Receiver operating characteristic curve analysis indicated that preoperative SII was a significant predictor for POCD, and the area under the curve was 0.909. Our data suggest that preoperative NLR, MLR, SII levels in the blood are related to the occurrence of POCD. Preoperative SII level is a prognostic biomarker of POCD in elderly patients after orthopedics operation. More clinical studies are needed to further verify the value of SII in POCD.