Attenuation of antibody titer of measles and rubella virus among university students of department of healthcare providers during 2015-2018 in Japan.
Attenuation of antibody titer of measles and rubella virus among university students of department of healthcare providers during 2015-2018 in Japan.
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2015-2018年日本医疗保健部门大学生麻疹和风疹病毒抗体滴度的衰减情况
DOI：
10.1016/j.vaccine.2021.05.040
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发表时间：
2021
期刊：
影响因子：
5.5
通讯作者：
N. Yamaguchi
中科院分区：
文献类型：
--
作者：
J. Kurita;Tomomi Uematsu;N. Sakurai;T. Sugawara;Y. Ohkusa;N. Yamaguchi
背景在日本，2015年3月确认消除麻疹。尽管如此，一些从国外输入病例的疫情甚至在认证后仍有报告。自2017年以来，一直在发生大规模风疹疫情。本研究探讨测量麻疹病毒的抗体滴度的衰减速度与风疹virus.MethodStudent科目出生于1996年4月2日至2000年4月1日在茨木县立大学健康科学为这项研究：177麻疹和114风疹。他们在随后的时间内有补充免疫和抗体的日期，并被判定为需要补充免疫。我们使用酶免疫法进行IgG抗体检测。我们回归麻疹或风疹抗体后滴度对前抗体滴度和接种后评价之间的持续时间的函数。根据调整后的决定系数选择持续时间的函数。ResultsFor麻疹，只有一个线性项的持续时间或日志的持续时间被发现是显着的，没有二次项。对于风疹，我们选择了一个五阶线性模型，该模型表明接种疫苗后麻疹抗体滴度将收敛到19.2。如果前抗体滴度为15，接种疫苗后迅速将滴度提高到26，然后每天减毒0.014。704天后，抗体滴度预计低于16，这是滴度的保护水平。然而，对于风疹，当以平均值评估接种前滴度时，下限为19.2。因此，保护可以维持很长一段时间。这种差异可能反映了各自疾病暴发的某些情况。结论：本报告描述了衰减速度和流行病学情况。衰减的速度预计会加快。因此，如果一种疾病几乎被消灭，可能需要每隔几年进行一次额外的疫苗接种，以保持保护水平。
BackgroundIn Japan, measles elimination was confirmed in March 2015. Nevertheless, some outbreaks with cases imported from abroad were reported even after certification. A large rubella outbreak has been occurring since 2017. This study examines measurement of the speed of attenuation of antibody titer for a measles virus comparison with rubella virus.MethodStudent subjects born from April 2, 1996 through April 1, 2000 were selected at Ibaraki Prefectural University of Health Sciences for this study: 177 for measles and 114 for rubella. They had available dates of additional immunization and antibodies in the following period and were judged as requiring additional immunization. We used enzyme immunoassay for IgG antibody testing. We regressed post-antibody titers of measles or rubella on pre-antibody titers and functions of duration between inoculation to post-evaluation. Functions of duration were selected according to the adjusted coefficient of determination.ResultsFor measles, only a linear term of duration or log of duration was found to be significant without the quadratic terms. For rubella, we selected a five-order linear model which indicated that titer after vaccination would converge to 19.2.DiscussionResults demonstrate that measles antibody decreased monotonically. If the pre-antibody titer was 15, vaccination raised titer quickly to 26; then it attenuated by 0.014 per day. Antibody titer is expected to be less than 16, which is the protection level of titer, after 704 days. For rubella, however, when pre-vaccination titer was evaluated at its average, the lower limit was 19.2. Therefore, protection can be maintained for a long time. This difference might reflect some circumstances of outbreaks of the respective diseases.Conclusion.This report describes the speed of attenuation and the epidemiological situation. The speed of attenuation can be expected to rise. Therefore, additional vaccination every several years might be necessary to maintain a protection level if a disease is almost eliminated.