Muscle glycogen availability and temperature regulation in humans.
Muscle glycogen availability and temperature regulation in humans.
复制标题
人体肌糖原的可用性和温度调节。
DOI：
10.1152/jappl.1989.66.1.72
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发表时间：
1989
影响因子：
3.3
通讯作者：
I. Jacobs
中科院分区：
文献类型：
--
作者：
L. Martineau;I. Jacobs
研究人员将 8 名半裸受试者浸入 18 摄氏度的水中 90 分钟或直至直肠温度 (Tre) 降至 35.5 摄氏度，研究了肌内糖原可用性对人体体温调节的影响。每位受试者在 3 周内浸泡 3 次。每次浸泡后进行 2.5 天的特定饮食和/或运动方案，旨在引起大型骨骼肌群中的低 (L)、正常 (N) 或高 (H) 糖原水平。每次浸入之前和之后，通过从股外侧肌获取的活组织检查来测定肌糖原浓度。浸泡前的肌内糖原浓度在 L、N 和 H 试验中存在显着差异（P 小于 0.01），平均分别为 247 +/- 15、406 +/- 23 和 548 +/- 42 (SE) mmol 葡萄糖单位.kg 干肌肉-1。与 N 或 H 相比，L 期间计算的浸泡前 30 分钟的代谢产热显着较低（P 小于 0.05）。在 L 浸泡期间，Tre 下降的速度比 N 或 H 浸泡期间更快（P 小于 0.05），并且在 L 浸泡期间，Tre 首次开始下降的时间也比 N 或 H 浸泡期间出现得更早。结果表明，低骨骼肌糖原水平与人体在水浸泡期间更快的身体冷却有关。然而，高于正常的肌糖原水平并不会增加耐冷能力。
The effects of intramuscular glycogen availability on human temperature regulation were studied in eight seminude subjects immersed in 18 degrees C water for 90 min or until rectal temperature (Tre) decreased to 35.5 degrees C. Each subject was immersed three times over a 3-wk period. Each immersion followed 2.5 days of a specific dietary and/or exercise regimen designed to elicit low (L), normal (N), or high (H) glycogen levels in large skeletal muscle groups. Muscle glycogen concentration was determined in biopsies taken from the vastus lateralis muscle before and after each immersion. Intramuscular glycogen concentration before the immersion was significantly different among the L, N, and H trials (P less than 0.01), averaging 247 +/- 15, 406 +/- 23, and 548 +/- 42 (SE) mmol glucose units.kg dry muscle-1, respectively. The calculated metabolic heat production during the first 30 min of immersion was significantly lower during L compared with N or H (P less than 0.05). The rate at which Tre decreased was more rapid during the L immersion than either N or H (P less than 0.05), and the time during the immersion at which Tre first began to decrease also appeared sooner during L than N or H. The results suggest that low skeletal muscle glycogen levels are associated with more rapid body cooling during water immersion in humans. Higher than normal muscle glycogen levels, however, do not increase cold tolerance.