A 2-year longitudinal study of skeletal muscle mass in women over 40?years of age with degenerative lumbar scoliosis
A 2-year longitudinal study of skeletal muscle mass in women over 40?years of age with degenerative lumbar scoliosis
复制标题
40 岁以上退变性腰椎侧凸女性骨骼肌质量的 2 年纵向研究
DOI：
10.1007/s00586-021-07038-1
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发表时间：
2022
影响因子：
2.8
通讯作者：
Ohtor
中科院分区：
文献类型：
--
作者：
Mizutani Masaya;Eguchi Yawara;Toyoguchi Toru;Orita Sumihisa;Inage Kazuhide;Shiga Yasuhiro;Furuya Takeo;Maki Satoshi;Nakamura Junichi;Hagiwara Shigeo;Aoki Yasuchika;Inoue Masahiro;Koda Masao;Takahashi Hiroshi;Akazawa Tsutomu;Shiko Yuki;Kawasaki Yohei;Ohtor
目的研究退行性腰椎侧凸(DLS)患者的骨骼肌量和骨密度的变化。方法对418例日本女性进行研究，其中DLS组50例，平均年龄76.4岁；对照组368例，平均年龄73.4岁。使用生物电阻抗分析仪测量全身骨骼肌质量。用DXA测量骨密度(BMD)。皮肤自发荧光(SAF)是皮肤中晚期糖基化终末产物的标志，使用分光镜进行测量。结果与对照组相比，DLS组的身高、体脂质量、握力、上肢肌肉质量和躯干肌肉质量显著降低，腰椎骨密度显著增加(p<； 0.05)。DLS组2年后脊柱对齐情况与基线相比无显著差异。在两年的随访期中，腰椎滑脱组的躯干肌肉质量下降幅度(-2.7%)明显高于对照组(-1.1%)(p<； 0.05)。未来有可能通过大规模的纵向研究来阐明脊柱后凸进展的机制。
PurposeWe investigated changes in skeletal muscle mass and bone mineral density in degenerative lumbar scoliosis (DLS) patients during a 2-year follow-up following diagnosis.MethodThis study included 418 Japanese women, identifying 50 patients for the DLS group (mean age 76.4 years) and 368 patients for the control group (mean age 73.4 years). Whole-body skeletal muscle mass was measured using a Bioelectrical Impedance Analyzer. Bone mineral density (BMD) was measured using DXA. Skin autofluorescence (SAF), a marker of advanced glycation end products in the skin, was measured using a spectroscope. Spinal alignment, skeletal muscle mass, BMD, grip strength, and SAF were examined and the amount of change 1 and 2 years from the initial examination for each item was compared between groups.ResultsHeight, body fat mass, grip strength, upper limb muscle mass, and trunk muscle mass in the DLS group were significantly lower, and lumbar spine BMD was significantly greater compared to controls at the first visit (p< 0.05). There was no significant difference in spinal alignment in the DLS group after 2 years compared with baseline. Trunk muscle mass also decreased significantly more in the DLS group (–2.7%) than in the control group (–1.1%) over the 2-year follow-up (p< 0.05).DiscussionIn this study, trunk muscle mass in the DLS group decreased about 2.4 times more in 2 years compared with the control group (p< 0.05). It may be possible to clarify the mechanism of kyphoscoliosis progression in the future with large-scale longitudinal studies.