Human schistosomiasis mansoni: intensity of infection differentially affects the production of interleukin-10, interferon-gamma and interleukin-13 by soluble egg antigen or adult worm antigen stimulated cultures.
Human schistosomiasis mansoni: intensity of infection differentially affects the production of interleukin-10, interferon-gamma and interleukin-13 by soluble egg antigen or adult worm antigen stimulated cultures.
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人曼氏血吸虫病：感染强度对可溶性卵抗原或成虫抗原刺激培养物产生的白细胞介素 10、干扰素 γ 和白细胞介素 13 的产生有不同影响。
DOI：
10.1016/j.trstmh.2003.11.009
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Correa-Oliveira,Rodrigo
中科院分区：
文献类型：
--
作者：
Silveira,AldaMS;Gazzinelli,Giovanni;Alves-Oliveira,LuciaF;Bethony,Jeffrey;Gazzinelli,Andrea;Carvalho-Queiroz,Claudia;Alvarez,MariaCarolinaB;Lima-Silva,FranciscoC;Prata,Aluizio;LoVerde,PhilipT;Correa-Oliveira,Rodrigo
The effect of the intensity of infection (eggs per gram faeces, epg) on the production of inteferon-γ (INF-γ), interleukin (IL)-10 and IL-13 by peripheral blood mononuclear cells (PBMCs) from individuals living in aSchistosoma mansoni-endemic area was evaluated. In vitro stimulation of PBMCs with soluble egg antigen (SEA) resulted in significantly higher secretion levels of IFN-γ in egg-negative individuals compared with those with an intensity of infection of more than 100 epg. In contrast, the egg-positive group produced significantly higher amounts of IL-10. Levels of IL-13 did not differ significantly between egg-positive and egg-negative groups. These findings suggest that IL-10 is an important cytokine in the control of the T helper cell (Th) type 1 responses during humanS. mansoniinfection, shifting the immune response from Th0 in egg-negative individuals from an endemic area to a Th2 polarization in chronic infected individuals.
