Elevated body mass index correlates with higher seminal plasma interleukin 8 levels and ultrasonographic abnormalities of the prostate in men attending an andrology clinic for infertility
Elevated body mass index correlates with higher seminal plasma interleukin 8 levels and ultrasonographic abnormalities of the prostate in men attending an andrology clinic for infertility
复制标题
DOI：
10.3275/7855
复制
发表时间：
2011-11-01
影响因子：
5.4
通讯作者：
Maggi, M.
中科院分区：
文献类型：
--
作者：
Lotti, F.;Corona, G.;Maggi, M.
背景：肥胖与全身性低度炎症状态有关。虽然肥胖和精液参数或前列腺疾病之间的关系已被调查，身体质量指数（BMI），前列腺炎症性疾病和彩色多普勒超声（CDU）的男性生殖道（MGT）之间的关联研究甚少。目的：探讨体重指数（BMI）与前列腺增生症（MGT）的CDU特征、前列腺炎症的体征和症状、精液参数之间的关系。材料/主题和方法：我们研究了222名男性寻求医疗保健的夫妇不孕症。根据世界卫生组织的分类，将受试者分为3组：正常体重组（n = 10），131，BMI=18.5-24.9 kg/m2），超重（数量= 71，BMI=25.0-29.9 kg/m2），肥胖（数量= 20，BMI >= 30.0 kg/m2）。所有患者在射精前后均行睾丸激素测定和精液分析，包括白细胞介素8（sIL-8），沿着阴囊和经直肠CDU。采用美国国立卫生研究院慢性前列腺炎症状指数问卷对患者的前列腺炎症状进行评估。结果如下：校正年龄和睾酮水平后，较高的BMI与前列腺体积和前列腺的几个CDU特征显著相关，包括宏观钙化、不均匀性、较高的动脉收缩期峰值流速（后者也校正了血压），但与睾丸、附睾、精囊异常无关。此外，较高的BMI和BMI等级与较高的sIL-8显著相关，sIL-8是前列腺炎性疾病的可靠替代标志物，即使在调整年龄后也是如此。相反，没有观察到BMI、前列腺炎临床症状或精液参数之间的相关性。结论：BMI较高的受试者可能会出现提示前列腺炎症的CDU和生化体征，尽管临床上并不明显。(J.年. Invest. 34：e336-e342，2011）（C）2011，Editrice Kurtis
Background: Obesity is associated with a systemic, low-grade inflammatory state. Although the relationship between obesity and semen parameters or prostate diseases has been previously investigated, the association between body mass index (BMI), prostate inflammatory diseases and color-Doppler ultrasound (CDU) of the male genital tract (MGT) has been poorly studied. Aim: To evaluate the association between BMI and CDU features of the MGT, signs and symptoms of prostate inflammation, semen parameters. Materials/Subjects and methods: We studied 222 men seeking medical care for couple infertility. According to the World Health Organization classification, subjects were divided into 3 groups: normal weight (no.=131, BMI=18.5-24.9 kg/m(2)), overweight (no.=71, BMI=25.0-29.9 kg/m(2)), obese (no.=20, BMI >= 30.0 kg/m(2)). All patients underwent simultaneous testosterone evaluation and seminal analysis, including interleukin 8 (sIL-8), along with scrotal and transrectal CDU, before and after ejaculation. Prostatitis symptoms were evaluated by National Institutes of HealthChronic Prostatitis Symptom Index questionnaire. Results: After adjusting for age and testosterone levels, higher BMI was significantly related to higher prostate volume and several CDU features of the prostate, including macro-calcifications, inhomogeneity, higher arterial peak systolic velocity (the latter adjusted also for blood pressure), but not with abnormalities of testis, epididymis, seminal vesicles. Furthermore, higher BMI and BMI class were significantly related to higher sIL-8, a reliable surrogate marker of prostate inflammatory diseases, even after adjustment for age. Conversely, no associations among BMI, clinical symptoms of prostatitis or semen parameters were observed. Conclusions: Subjects with higher BMI might develop CDU and biochemical signs suggestive of prostate inflammation, although not clinically overt. (J. Endocrinol. Invest. 34: e336-e342, 2011) (C)2011, Editrice Kurtis