Poor sleep increases the prospective risk for recurrent events in middle-aged women with coronary disease -: The Stockholm Female Coronary Risk Study
Poor sleep increases the prospective risk for recurrent events in middle-aged women with coronary disease -: The Stockholm Female Coronary Risk Study
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DOI：
10.1016/s0022-3999(02)00475-0
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发表时间：
2003-02-01
影响因子：
4.7
通讯作者：
Orth-Gomér, K
中科院分区：
文献类型：
--
作者：
Leineweber, C;Kecklund, G;Orth-Gomér, K
目标：我们。研究了睡眠问题对女性冠心病患者预后的影响，并研究了睡眠问题和心脏事件之间的关系是否可以用抑郁症来解释。研究方法：对1991年至1994年在斯德哥尔摩因急性冠脉综合征入院的所有65岁或以下女性患者进行5年的复发性冠脉事件随访。在基线时使用标准化问卷测量睡眠抱怨和抑郁。睡眠质量、睡眠恢复功能和打鼾通过Karolinska睡眠问卷（KSQ）进行评估，抑郁症状通过Pearlin开发的问卷进行评估。结果：睡眠质量差与心脏事件复发有关。在对年龄和标准危险因素进行多变量校正后，睡眠质量差的女性与睡眠质量好的女性相比的风险比（HR）为2.5（95%CI：1.2-5.2）。控制抑郁症并没有实质性地改变这个结果。醒来时没有得到充分休息也会产生类似的风险增加（HR=2.4; 95% CI：1.2-4.6）。睡眠质量差和抑郁症的妇女比没有这些投诉的妇女预后更差（HR=2.6; 95%CI：1.0-6.4）。重度打鼾与预后无关。结论：我们的研究结果表明，睡眠不佳和睡眠没有恢复功能与女性冠心病患者预后不良有关。这种关联不能用抑郁症状或标准的冠状动脉危险因素来解释。(C)2003年爱思唯尔科学公司All rights reserved.
Objective: We. investigated the prognostic impact of sleep complaints in women with CHD and also examined whether the association between sleep problems and cardiac events could be explained by depression. Methods: All women patients, aged 65 or under who were admitted with an acute coronary syndrome between 1991 and 1994 in Stockholm, were followed for 5 years for recurrent coronary events. Sleep complaints and depression were measured at baseline using standardized questionnaires. Quality of sleep, restorative function of sleep, and snoring were assessed by the Karolinska Sleep Questionnaire (KSQ), and depressive symptoms by a questionnaire developed by Pearlin. Results: Poor sleep quality was associated with recurrent cardiac events. After multivariate adjustment for age, and standard risk factors, the hazard ratio (HR) for women with poor as compared with good sleep quality was 2.5 (95% Cl: 1.2-5.2). Controlling for depression did not change this result substantial. Not waking up well-rested yielded a similarly increased risk (HR=2.4; 95% CI: 1.2-4.6). Women with both poor sleep quality and depression had a worse prognosis than women free from these complaints (HR=2.6; 95% Cl: 1.0-6.4). Heavy snoring was not related to prognosis. Conclusions: Our results indicate that poor sleep and sleep without a restorative function are associated with poor prognosis in female coronary patients. This association is not explained by depressive symptoms or by standard coronary risk factors. (C) 2003 Elsevier Science Inc. All rights reserved.