ANALYSIS OF CABLE PROPERTIES OF FROG VENTRICULAR MYOCARDIUM
ANALYSIS OF CABLE PROPERTIES OF FROG VENTRICULAR MYOCARDIUM
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DOI：
10.1113/jphysiol.1978.sp012499
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发表时间：
1978-01-01
影响因子：
5.5
通讯作者：
FRY, CH
中科院分区：
文献类型：
--
作者：
CHAPMAN, RA;FRY, CH
测量了蛙心室肌的被动和主动电参数。细胞质电阻率通过以下微电极在细胞穿透时的电阻变化来确定。使用直流和交流电的一维电缆分析揭示了归因于表面膜的单个时间常数的存在。纵向阻抗测量表明，第二个时间常数是存在于细胞内的途径。细胞之间的电阻很低，因此动作电位可以通过局部电路从一个细胞传播到另一个细胞。进行了三维电缆分析，并与附录中提供的简化数学模型进行了比较，该模型非常接近实验情况。
The passive and active electrical parameters of frog ventricular myocardium were measured. The cytoplasmic resistivity was determined by following changes in the resistance of a micro-electrode on penetration of a cell. Unidimensional cable analysis using direct and alternating currents revealed the presence of a single time constant attributed to the surface membrane. Longitudinal impedance measurements indicate that a 2nd time constant is present in the intracellular pathway. The resistance between cells is low so that action potentials can propagate from cell to cell by local circuits. A 3-dimensional cable analysis was performed and compared to a simplified mathematical model which is presented in an appendix and which closely approximates the experimental situation.