Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation.
Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation.
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DOI：
10.1155/2016/6591703
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发表时间：
2016
影响因子：
4.6
通讯作者：
Iqbal AJ
中科院分区：
文献类型：
--
作者：
Kapellos TS;Iqbal AJ
巨噬细胞充当前哨细胞，不断监测宿主环境的感染或损伤。巨噬细胞已被证明表现出一系列激活的表型，通常可以归类为 M1/M2 范式。 M1 巨噬细胞分泌促炎细胞因子和趋化因子，例如 TNF-α、IL-6、IL-12、CCL4 和 CXCL10，并诱导吞噬作用和氧化依赖性杀伤机制。相比之下，M2 巨噬细胞支持伤口愈合和炎症消退。在过去的十年中，人们对了解调节巨噬细胞激活的机制越来越感兴趣。特别是，M1 或 M2 激活状态的表观遗传控制已被证明依赖于与炎症相关基因相邻的组蛋白的翻译后修饰。甲基转移酶、去甲基化酶、乙酰转移酶和脱乙酰酶引起的组蛋白甲基化和乙酰化的变化都会影响巨噬细胞表型的生成方式。在这篇综述中，我们总结了巨噬细胞极化为 M1 或 M2 状态的表观遗传调控领域的最新进展，特别关注与这些表型相关的细胞因子和趋化因子谱。
Macrophages function as sentinel cells, which constantly monitor the host environment for infection or injury. Macrophages have been shown to exhibit a spectrum of activated phenotypes, which can often be categorised under the M1/M2 paradigm. M1 macrophages secrete proinflammatory cytokines and chemokines, such as TNF-α, IL-6, IL-12, CCL4, and CXCL10, and induce phagocytosis and oxidative dependent killing mechanisms. In contrast, M2 macrophages support wound healing and resolution of inflammation. In the past decade, interest has grown in understanding the mechanisms involved in regulating macrophage activation. In particular, epigenetic control of M1 or M2 activation states has been shown to rely on posttranslational modifications of histone proteins adjacent to inflammatory-related genes. Changes in methylation and acetylation of histones by methyltransferases, demethylases, acetyltransferases, and deacetylases can all impact how macrophage phenotypes are generated. In this review, we summarise the latest advances in the field of epigenetic regulation of macrophage polarisation to M1 or M2 states, with particular focus on the cytokine and chemokine profiles associated with these phenotypes.