Sequence to Structure (S2S): display, manipulate and interconnect RNA data from sequence to structure
Sequence to Structure (S2S): display, manipulate and interconnect RNA data from sequence to structure
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DOI：
10.1093/bioinformatics/bti504
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发表时间：
2005-08-01
期刊：
影响因子：
5.8
通讯作者：
Westhof, E
中科院分区：
文献类型：
--
作者：
Jossinet, F;Westhof, E
有效的RNA序列操作（如多重比对）需要受到RNA结构折叠规则的约束。近年来，随着与细菌核糖体亚基结构相似的几种大RNA结构的积累，结构知识急剧增加。然而，RNA社区中没有工具提供一种简单的方法来使用可用的三维信息在序列水平上链接和整合所取得的进展。序列到结构（S2 S）提出了一个框架，其中用户可以轻松地显示，操作和互连异质RNA数据，如多序列比对，二级和三级结构。S2 S已使用Java语言实现，并已在UNIX系统（如Linux和MacOSX）下开发和测试。可用性：S2 S可在http://bioinformatics.org/S2S/Contact上获得：f. ibmc.u-strasbg.fr
Efficient RNA sequence manipulations (such as multiple alignments) need to be constrained by rules of RNA structure folding. The structural knowledge has increased dramatically in the last years with the accumulation of several large RNA structures similar to those of the bacterial ribosome subunits. However, no tool in the RNA community provides an easy way to link and integrate progress made at the sequence level using the available three-dimensional information. Sequence to Structure (S2S) proposes a framework in which an user can easily display, manipulate and interconnect heterogeneous RNA data, such as multiple sequence alignments, secondary and tertiary structures. S2S has been implemented using the Java language and has been developed and tested under UNIX systems, such as Linux and MacOSX.Availability: S2S is available at http://bioinformatics.org/S2S/Contact: f.jossinet@ibmc.u-strasbg.fr