Randomized, controlled trial of long-term moderate exercise training in chronic heart failure - Effects on functional capacity, quality of life, and clinical outcome
Randomized, controlled trial of long-term moderate exercise training in chronic heart failure - Effects on functional capacity, quality of life, and clinical outcome
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DOI：
10.1161/01.cir.99.9.1173
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发表时间：
1999-03-09
期刊：
影响因子：
37.8
通讯作者：
Purcaro, A
中科院分区：
文献类型：
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作者：
Belardinelli, R;Georgiou, D;Purcaro, A
背景：运动训练（ET）是否是慢性心力衰竭（CHF）的有益治疗仍然存在争议。方法和结果：为了确定长期适度的ET是否能改善CHF患者的功能能力和生活质量，以及这些效果是否转化为有利的结果，最初招募了110例稳定型CHF患者，99例（59+/-14岁；88名男性和11名女性）随机分为两组。一组（T组，n=50）在峰值(V) /点（O2）的60%进行ET治疗，最初每周3次，持续8周，然后每周2次，持续1年。另一组（NT组，n=49）不运动。在基线、2个月和14个月时，所有患者都进行了心肺运动试验，74例缺血性心脏病患者（T组37例，NT组37例）进行了心肌显像检查。采用问卷调查的方式评估患者的生活质量。94例患者完成了方案（T组48例，NT组46例），仅T组患者观察到变化。2个月时，峰值iio和铊活性评分均有所改善(分别为18%和24%
Background-It is still a matter of debate whether exercise training (ET) is a beneficial treatment in chronic heart failure (CHF).Methods and Results-To determine whether long-term moderate ET improves functional capacity and quality of life in patients with CHF and whether these effects translate into a favorable outcome, 110 patients with stable CHF were initially recruited, and 99 (59+/-14 years of age; 88 men and 11 women) were randomized into 2 groups. One group (group T, n=50) underwent ET at 60% of peak (V) over dot (O2), initially 3 times a week for 8 weeks, then twice a week for 1 year. Another group (group NT, n=49) did not exercise. At baseline and at months 2 and 14, all patients underwent a cardiopulmonary exercise test, while 74 patients (37 in group T and 37 in group NT) with ischemic heart disease underwent myocardial scintigraphy. Quality of life was assessed by questionnaire. Ninety-four patients completed the protocol (48 in group T and 46 in group NT), Changes were observed only in patients in group T. Both peak iio, and thallium activity score improved at 2 months (18% and 24%, respectively; P