DIFFERENTIAL REGULATION OF RAT AT1A AND AT1B RECEPTOR MESSENGER-RNA
DIFFERENTIAL REGULATION OF RAT AT1A AND AT1B RECEPTOR MESSENGER-RNA
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DOI：
10.1016/0006-291x(92)92384-a
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发表时间：
1992-10-15
影响因子：
3.1
通讯作者：
KINOSHITA, M
中科院分区：
文献类型：
--
作者：
IWAI, N;INAGAMI, T;KINOSHITA, M
大鼠1型血管紧张素II受体有两种亚型，即Ia型和Ib型。用竞争性聚合酶链反应方法研究了这两种亚型受体mRNA表达的调控。双侧肾切除后，肝脏中Ia型mRNA表达呈阴性，肾上腺中Ib型mRNA表达呈阳性。16周龄Spontaneous hypertension大鼠心室中AT 1b受体mRNA的表达水平高于同龄Wistar-Kyoto大鼠心室中AT 1a受体mRNA的表达水平，而两品系大鼠心室中AT 1a mRNA的表达水平在该年龄段几乎相似。虽然Ia型和Ib型具有几乎相似的功能特性，但它们的mRNA表达受到差异调节。
Rat type 1 angiotensin II receptor has two subtypes, namely type la and type 1b. The regulation of the expressions of these two subtype receptor mRNAs was studied by using a competitive polymerase chain reaction method. The expression of the type la mRNA in the liver was negatively and that of the type 1b mRNA in the adrenal was positively modulated by bilateral nephrectomy. In the ventricle of 16 week old Spontaneously hypertensive rat, the expression level of the ATlb receptor mRNA was higher than that in the ventricle of the age-matched Wistar-Kyoto rat, while the expression levels of the AT1a mRNA in the ventricle were almost similar between the two strains at this age. Although type la and type 1b have almost similar functional properties, the expressions of their mRNAs were differentially regulated.