Influence of Sexuality in Functional Recovery after Spinal Cord Injury in Rats.
Influence of Sexuality in Functional Recovery after Spinal Cord Injury in Rats.
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DOI：
10.22038/abjs.2016.5816
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
M. Emamhadi;B. Soltani;P. Babaei;H. Mashhadinezhad;S. Ghadarjani
中科院分区：
文献类型：
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作者：
M. Emamhadi;B. Soltani;P. Babaei;H. Mashhadinezhad;S. Ghadarjani
背景脊髓损伤(SCI)是一种主要的临床症状，人们经常进行研究以寻找合适的治疗方案。然而，脊髓损伤后有一定程度的自发恢复，性别被认为是恢复的一个促成因素，但这一点是有争议的。本研究旨在比较性二形性对Wistar大鼠脊髓损伤后自然恢复的影响。方法在T9水平压迫脊髓，造成脊髓挫伤，造成脊髓损伤模型。每天对每只大鼠进行常规护理。用LSS评分系统测量大鼠的运动能力，并比较雌雄大鼠的恢复率。结果男女患者在康复方面差异无统计学意义。结论女性似乎不是脊髓损伤后康复的预后因素。然而，这项初步研究应该在其他动物和更大的队列中重复进行。
BACKGROUND Spinal cord injury (SCI) is a major clinical condition and research is commonly done to find suitable treatment options. However, there are some degrees of spontaneous recovery after SCI and gender is said to be a contributing factor in recovery, but this is controversial. This study was done to compare the effects of sexual dimorphism on spontaneous recovery after spinal cord injury in Wistar Rats. METHODS Spinal cord lesions were made by compressing the cord at T9 level and making a spinal cord contusion. Routine care of each rat was done daily. The LSS scoring system was used to measure the locomotion of these rats and to compare the recovery rate between male and female rats. RESULTS The results suggested that there was no significant difference between the two sex in recovery. CONCLUSIONS To be female does not seem to be a prognostic factor for recovery after SCI. However, this preliminary study should be repeated in other animals and in larger cohorts.