CrossTalk proposal: Interstitial cells are involved and physiologically important in neuromuscular transmission in the gut
CrossTalk proposal: Interstitial cells are involved and physiologically important in neuromuscular transmission in the gut
复制标题
CrossTalk 提案：间质细胞参与肠道神经肌肉传递，并且在生理上很重要
DOI：
10.1113/jp271600
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Friebe A
中科院分区：
文献类型：
--
作者：
Sanders KM;Ward SM;Friebe A
传统的观点认为，肠运动神经元与平滑肌细胞(SMC)之间的通讯仅通过容量传递(Sarna，2008)。然而，胃肠道的神经肌肉机构是复杂的，存在Cajal间质细胞(ICC；KIT+细胞)和PDGFRα+细胞(抗血小板衍生生长因子受体α抗体标记的细胞)，它们聚集在运动神经元的曲张纤维上，与SMC形成缝隙连接。这三种类型的细胞形成一个电合胞体(根据三种细胞类型中每种细胞类型的第一个字母)，称为SIP合胞体(Sanders等人。2012年)。SIP细胞表达运动神经递质受体，并对神经递质做出反应。提示间质细胞由运动神经元支配，胃肠肌的生理反应是SIP型合胞体的综合产物，ICC和PDGFRα+细胞与胃肠肌运动神经元的突起密切相关。在ICC的情况下，非常接近的结(<；20 nm)是常见的。精索静脉曲张和SMC之间也有这种连接的报道，但似乎不太常见(丹尼尔)
Traditional thinking has held that enteric motor neurons communicate with smooth muscle cells (SMCs) exclusively by volume transmission (Sarna, 2008). However, the neuromuscular apparatus of the gastrointestinal (GI) tract is complicated by the presence of interstitial cells of Cajal (ICC; KIT+ cells) and PDGFRα+ cells (cells labelled by antibodies against platelet-derived growth factor receptor α), which cluster along varicose fibres of motor neurons and form gap junctions with SMCs. The three types of cells form an electrical syncytium known (from the first letter of each of the three cell types) as the SIP syncytium (Sanders et al. 2012). SIP cells express receptors for motor neurotransmitters and respond to neurotransmitters. These observations suggest that interstitial cells are innervated by motor neurons and physiological responses of GI muscles are the integrated product of the SIP syncytium.ICC and PDGFRα+ cells lie in close proximity to varicosities of motor neurons in GI muscles. In the case of ICC, very close junctions (< 20 nm) are common. Junctions of this sort have also been reported between varicosities and SMCs, but these appear less common (Daniel
登录
查看更多内容
影响因子：
5.5
作者：
Lies, Barbara;Beck, Katharina;Friebe, Andreas
通讯作者：
Friebe, Andreas
影响因子：
5.5
作者：
Kurahashi, Masaaki;Mutafova-Yambolieva, Violeta;Sanders, Kenton M.
通讯作者：
Sanders, Kenton M.
DOI：
10.1152/ajpgi.00082.2014
发表时间：
2014-07-01
影响因子：
4.5
作者：
Lies, Barbara;Gil, Victor;Friebe, Andreas
通讯作者：
Friebe, Andreas
影响因子：
29.4
作者：
Groneberg, Dieter;Lies, Barbara;Friebe, Andreas
通讯作者：
Friebe, Andreas
影响因子：
5.5
作者：
Groneberg, Dieter;Zizer, Eugen;Friebe, Andreas
通讯作者：
Friebe, Andreas