Plasma metabolite biomarkers related to secondary hyperparathyroidism and parathyroid hormone
Plasma metabolite biomarkers related to secondary hyperparathyroidism and parathyroid hormone
复制标题
继发性甲状旁腺功能亢进症和甲状旁腺激素相关的血浆代谢生物标志物
DOI：
10.1002/jcb.28846
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发表时间：
2019-09-01
影响因子：
4
通讯作者：
Jiang, Hong
中科院分区：
文献类型：
--
作者：
Shen, Qixia;Xiang, Wenyu;Jiang, Hong
背景：高磷血症、低钙血症和甲状旁腺激素（PTH）升高是尿毒症合并继发性甲状旁腺功能亢进（SHPT）患者的典型异常。然而，与SHPT相关的代谢失衡尚不清楚。方法将15例甲状旁腺激素（iPTH）水平完好的SHPT患者作为术前（PR）组，15例因甲状旁腺功能亢进而行甲状旁腺切除术加前臂移植并达到iPTH水平的年龄和性别匹配的对照组
Background Hyperphosphatemia, hypocalcemia, and elevation of parathyroid hormone (PTH) are typical abnormalities of uremic patients with Secondary hyperparathyroidism (SHPT). However, metabolic imbalance associated with SHPT is not well understood. Methods A total of 15 SHPT patients with an intact parathyroid hormone (iPTH) level > 600 pg/mL were set as preoperative (PR) group, 15 age- and gender-matched controls who had undergone parathyroidectomy plus forearm transplantation because of hyperparathyroidism and achieved an iPTH level