CLINICAL CHARACTERISTICS OF 28 PATIENTS WITH DIABETES AND COVID-19 IN WUHAN, CHINA
CLINICAL CHARACTERISTICS OF 28 PATIENTS WITH DIABETES AND COVID-19 IN WUHAN, CHINA
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中国武汉 28 名糖尿病合并 COVID-19 患者的临床特征
DOI：
10.4158/ep-2020-0108
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发表时间：
2020-06-01
影响因子：
4.2
通讯作者：
Shi, Xiaoli
中科院分区：
文献类型：
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作者：
Wang, Feng;Yang, Yan;Shi, Xiaoli
目的：之前关于 2019 年冠状病毒病 (COVID-19) 的研究基于一般人群的信息。我们旨在进一步明确糖尿病合并COVID-19的临床特征。方法：从2020年1月29日至2020年2月10日入组28名糖尿病合并COVID-19患者，并于2020年2月22日进行最终随访。对流行病学、人口统计学、临床、实验室、治疗和结果数据进行分析。结果：28名患者的平均年龄为68.6+/- 9.0 年。大多数（75%）患者是男性。只有 39.3% 的患者有明确的 COVID-19 暴露史。最常见的症状为发热（92.9%）、干咳（82.1%）和乏力（64.3%），其次是呼吸困难（57.1%）、厌食（57.1%）、腹泻（42.9%）、咳痰（25.0%）和恶心（21.4%）。十四名患者被送入重症监护室（ICU）。 ICU 和非 ICU 患者的血红蛋白 Ale 水平相似。与非 ICU 患者相比，ICU 患者呼吸频率较高，随机血糖、天冬氨酸转氨酶、胆红素、肌酸、脑钠肽 N 端激素原、肌钙蛋白 I、D-二聚体、降钙素原、C 反应蛋白、铁蛋白、白细胞介素 (IL)-2R、IL-6 和 11..-8 水平较高。 14 名 ICU 患者中有 11 名接受无创通气，7 名患者接受有创机械通气。 ICU组有12例患者死亡，非ICU组无患者死亡。结论：ICU病例的器官衰竭率和死亡率高于非ICU病例。糖尿病合并 COVID-19 患者的不良预后表明这些患者需要更多的监督。
Objective: Previous studies on coronavirus disease 2019 (COVID-19) were based on information from the general population. We aimed to further clarify the clinical characteristics of diabetes with COVID-19.Methods: Twenty-eight patients with diabetes and COVID-19 were enrolled from January 29, 2020, to February 10, 2020, with a final follow-up on February 22, 2020. Epidemiologic, demographic, clinical, laboratory, treatment, and outcome data were analyzed.Results: The average age of the 28 patients was 68.6 +/- 9.0 years. Most (75%) patients were male. Only 39.3% of the patients had a clear exposure of COVID-19. Fever (92.9%), dry cough (82.1%), and fatigue (64.3%) were the most common symptoms, followed by dyspnea (57.1%), anorexia (57.1%), diarrhea (42.9%), expectoration (25.0%), and nausea (21.4%). Fourteen patients were admitted to the intensive care unit (ICU). The hemoglobin Ale level was similar between ICU and non-ICU patients. ICU patients had a higher respiratory rate, higher levels of random blood glucose, aspartate transaminase, bilirubin, creatine, N-terminal prohormone of brain natriuretic peptide, troponin I, D-dimers, procalcitonin, C-reactive protein, ferritin, interleukin (IL)-2R, IL-6, and 11..-8 than non-ICU patients. Eleven of 14 ICU patients received noninvasive ventilation and 7 patients received invasive mechanical ventilation. Twelve patients died in the ICU group and no patients died in the non-ICU group.Conclusion: ICU cases showed higher rates of organ failure and mortality than non-ICU cases. The poor outcomes of patients with diabetes and COVID-19 indicated that more supervision is required in these patients.